The effects of clopidogrel and omeprazole on platelet function in normal dogs.
The effects of clopidogrel and omeprazole on platelet function in normal dogs.
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氯吡格雷和奥美拉唑对正常狗血小板功能的影响。
DOI：
10.1111/jvp.12340
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发表时间：
2017-04
影响因子：
1.3
通讯作者：
Thomason J
中科院分区：
文献类型：
--
作者：
Thames BE;Lovvorn J;Papich MG;Wills R;Archer T;Mackin A;Thomason J
奥美拉唑与氯吡格雷同时使用，以减少胃肠道不良反应。在人体中，同时使用这两种药物可降低氯吡格雷的抗血小板疗效。我们的目的是确定奥美拉唑和氯吡格雷对健康犬血小板功能的影响。一项交叉研究使用比浊法聚集测定法（ADP和胶原）和PFA-100®（带胶原/ADP笔芯），在8只健康犬中评价氯吡格雷（1 mg/kg/24 h PO）、奥美拉唑（1 mg/kg/24 h PO）以及氯吡格雷和奥美拉唑联合给药期间的血小板功能。还测量了药物代谢物浓度。与治疗前相比，在第3天和第5天，以ADP为激动剂，氯吡格雷和氯吡格雷/奥美拉唑组的聚集测定最大振幅均显著降低。第3天和第5天，氯吡格雷组与氯吡格雷/奥美拉唑组之间的以下指标无显著差异：ADP或胶原激动剂的肌张力测定振幅和PFA-100®闭合时间。与氯吡格雷组相比，第3天和第5天氯吡格雷/奥美拉唑组的氯吡格雷代谢物浓度显著更高。在健康犬中同时给予奥美拉唑和氯吡格雷可增加非活性氯吡格雷代谢物的血浆浓度，但不会显著改变氯吡格雷的抗血小板作用。
Omeprazole is used concurrently with clopidogrel to reduce gastrointestinal adverse effects. In humans, the concurrent use of these two drugs can reduce the anti-platelet efficacy of clopidogrel. Our objective was to determine the effects of omeprazole and clopidogrel on platelet function in healthy dogs. A cross-over study utilized turbidimetric aggregometry (ADP and collagen) and the PFA-100® with the collagen/ADP cartridge to evaluate platelet function in eight healthy dogs during the administration of clopidogrel (1mg/kg/24h PO), omeprazole (1mg/kg/24h PO), and a combination of clopidogrel and omeprazole. Drug metabolite concentrations were also measured. Compared to pretreatment, on Days 3 and 5, with ADP as the agonist, there was a significant decrease in maximum amplitude on aggregometry for both clopidogrel and clopidogrel/omeprazole groups. The following revealed no significant differences between clopidogrel and clopidogrel/omeprazole groups when compared on Days 3 and 5: amplitude on aggegometry with ADP or collagen agonists, and PFA-100® closure times. When compared to the clopidogrel group, clopidogrel metabolite concentrations in the clopidogrel/omeprazole group were significantly higher on Days 3 and 5. The concurrent administration of omeprazole and clopidogrel in healthy dogs increased the plasma concentration of an inactive clopidogrel metabolite, but does not significantly alter the anti-platelet effects of clopidogrel.
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影响因子：
3.3
作者：
Edwards, Abbie;Jakubowski, Joseph A.;Harrison, Paul
通讯作者：
Harrison, Paul
影响因子：
2.6
作者：
Dudley, A.;Thomason, J.;Lunsford, K.
通讯作者：
Lunsford, K.
影响因子：
168.9
作者：
Collet, Jean-Philippe;Hulot, Jean-Sebastien;Montalescot, Gilles
通讯作者：
Montalescot, Gilles
影响因子：
3.9
作者：
Boulenc, Xavier;Djebli, Nassim;Hurbin, Fabrice
通讯作者：
Hurbin, Fabrice
影响因子：
4.8
作者：
Siller-Matula, Jolanta M.;Spiel, Alexander O.;Jilma, Bernd
通讯作者：
Jilma, Bernd