The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites.
The compact genome of Giardia muris reveals important steps in the evolution of intestinal protozoan parasites.
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DOI：
10.1099/mgen.0.000402
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发表时间：
2020-08
影响因子：
3.9
通讯作者：
Jerlström-Hultqvist J
中科院分区：
文献类型：
--
作者：
Xu F;Jiménez-González A;Einarsson E;Ástvaldsson Á;Peirasmaki D;Eckmann L;Andersson JO;Svärd SG;Jerlström-Hultqvist J
Diplomonad parasites of the genus Giardia have adapted to colonizing different hosts, most notably the intestinal tract of mammals. The human-pathogenic Giardia species, Giardia intestinalis, has been extensively studied at the genome and gene expression level, but no such information is available for other Giardia species. Comparative data would be particularly valuable for Giardia muris, which colonizes mice and is commonly used as a prototypic in vivo model for investigating host responses to intestinal parasitic infection. Here we report the draft-genome of G. muris. We discovered a highly streamlined genome, amongst the most densely encoded ever described for a nuclear eukaryotic genome. G. muris and G. intestinalis share many known or predicted virulence factors, including cysteine proteases and a large repertoire of cysteine-rich surface proteins involved in antigenic variation. Different to G. intestinalis, G. muris maintains tandem arrays of pseudogenized surface antigens at the telomeres, whereas intact surface antigens are present centrally in the chromosomes. The two classes of surface antigens engage in genetic exchange. Reconstruction of metabolic pathways from the G. muris genome suggest significant metabolic differences to G. intestinalis. Additionally, G. muris encodes proteins that might be used to modulate the prokaryotic microbiota. The responsible genes have been introduced in the Giardia genus via lateral gene transfer from prokaryotic sources. Our findings point to important evolutionary steps in the Giardia genus as it adapted to different hosts and it provides a powerful foundation for mechanistic exploration of host–pathogen interaction in the G. muris–mouse pathosystem.
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影响因子：
3.8
作者：
Einarsson, Elin;Troell, Karin;Svard, Staffan G.
通讯作者：
Svard, Staffan G.
影响因子：
4.8
作者：
DuBois, Kelly N.;Abodeely, Marla;Sajid, Mohammed
通讯作者：
Sajid, Mohammed
影响因子：
10.7
作者：
Hoang DT;Chernomor O;von Haeseler A;Minh BQ;Vinh LS
通讯作者：
Vinh LS
影响因子：
4
作者：
Carolina Touz, Maria;Silvana Ropolo, Andrea;Romina Rivero, Maria;Veronica Vranych, Cecilia;Conrad, John Thomas;Svard, Staffan Gunnar;Nash, Theodore Elliott
通讯作者：
Nash, Theodore Elliott
DOI：
10.4049/jimmunol.1700824
发表时间：
2018-07-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dann SM;Le CHY;Hanson EM;Ross MC;Eckmann L
通讯作者：
Eckmann L