Biological impacts on the lungs in rats internally exposed to radioactive (56)MnO(2) particle.
Biological impacts on the lungs in rats internally exposed to radioactive (56)MnO(2) particle.
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DOI：
10.1038/s41598-021-90443-9
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发表时间：
2021-05-26
影响因子：
4.6
通讯作者：
Hoshi M
中科院分区：
文献类型：
--
作者：
Fujimoto N;Ruslanova B;Abishev Z;Chaizhunussova N;Shabdarbayeva D;Amantayeva G;Farida R;Sandybayev M;Nagano K;Zhumadilov K;Kaprin A;Ivanov S;Stepanenko V;Hoshi M
为了了解广岛和长崎原子弹爆炸对幸存者的辐射影响，除了直接从原子弹接收到的初始辐射之外，还应考虑土壤中中子诱发的放射性同位素的辐射。 56Mn 同时发射 β 粒子和 γ 射线，是炸弹中子在土壤中产生的主要放射性同位素之一。因此，我们研究了雄性 Wistar 大鼠肺部内部暴露于 56MnO2 颗粒的生物效应，并与外部 60Co-γ 辐射的效应进行比较。 56MnO2暴露动物的肺部内照射吸收剂量在25至65 mGy之间，而全身剂量在41至100 mGy之间。暴露后第 3 天和第 61 天对动物进行检查。没有与56MnO2颗粒暴露相关的显着病理变化。然而，56MnO2 组暴露后第 3 天，肺组织中水通道蛋白 5 的 mRNA 和蛋白表达显着增加（最高剂量组分别增加 1.6 倍和 2.9 倍）。在56MnO2最高剂量组中，Smad7 mRNA表达也显着升高30%。我们的数据表明，内部暴露于 56MnO2 会引起显着的生物反应，包括肺部基因表达变化，而外部 2 Gy 的 60Co-γ 照射没有显示任何变化。
To understand the radiation effects of the atomic bombing of Hiroshima and Nagasaki among the survivors, radiation from neutron-induced radioisotopes in soil should be considered in addition to the initial radiation directly received from the bombs. 56Mn, which emits both β particles and γ-rays, is one of the dominant radioisotopes created in soil by neutrons from the bomb. Thus we investigated the biological effects of internal exposure to 56MnO2 particle in the lung of male Wistar rats comparing to the effects of external 60Co-γ irradiation. Absorbed doses of internal irradiation of lungs were between 25 and 65 mGy in 56MnO2-exposed animals, while the whole body doses were between 41 and 100 mGy. Animals were examined on days 3 and 61 after the exposure. There were no remarkable pathological changes related to 56MnO2 particle exposure. However, mRNA and protein expressions of aquaporin 5 increased significantly in the lung tissue on day 3 postexposure in 56MnO2 groups (by 1.6 and 2.9 times, respectively, in the highest dose group). Smad7 mRNA expression was also significantly elevated by 30% in the highest dose group of 56MnO2. Our data demonstrated that internal exposure to 56MnO2 induced significant biological responses including gene expression changes in the lungs, while external 60Co-γ irradiation of 2 Gy did not show any changes.
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影响因子：
1.7
作者：
Stepanenko V;Kaprin A;Ivanov S;Shegay P;Zhumadilov K;Petukhov A;Kolyzhenkov T;Bogacheva V;Zharova E;Iaskova E;Chaizhunusova N;Shabdarbayeva D;Amantayeva G;Baurzhan A;Ruslanova B;Abishev Z;Apbassova M;Kairkhanova Y;Uzbekov D;Khismetova Z;Zhunussov Y;Fujimoto N;Sato H;Shichijo K;Nakashima M;Sakaguchi A;Toyoda S;Kawano N;Ohtaki M;Otani K;Endo S;Yamamoto M;Hoshi M
通讯作者：
Hoshi M
影响因子：
2.3
作者：
Verkman, A. S.
通讯作者：
Verkman, A. S.
影响因子：
--
作者：
Fujimoto, Nariaki;Suzuki, Tomoharu;Kitamura, Shigeyuki
通讯作者：
Kitamura, Shigeyuki
DOI：
10.1016/s0360-3016(00)00482-x
发表时间：
2000-07-01
影响因子：
7
作者：
Rübe, CE;Uthe, D;Rübe, C
通讯作者：
Rübe, C
DOI：
10.1016/0360-3016(77)90159-6
发表时间：
1977-01-01
影响因子：
7
作者：
TRAVIS, EL;HARLEY, RA;HARGROVE, HB
通讯作者：
HARGROVE, HB