The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.
The epidemic characteristics and changing trend of hemorrhagic fever with renal syndrome in Hubei Province, China.
复制标题
湖北省肾综合征出血热流行特征及变化趋势
DOI：
10.1371/journal.pone.0092700
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yang ZQ
中科院分区：
文献类型：
--
作者：
Zhang YH;Ge L;Liu L;Huo XX;Xiong HR;Liu YY;Liu DY;Luo F;Li JL;Ling JX;Chen W;Liu J;Hou W;Zhang Y;Fan H;Yang ZQ
背景肾综合征出血热（HFRS）是由布尼亚病毒科的不同汉坦病毒引起的。HFRS是一种暴发性传染病，在全球范围内发生，在中国所有31个省都是地方病。自1957年湖北省报告首例HFRS病例以来，该病已在全省范围内蔓延，湖北省已成为20世纪80年代中国HFRS病例报告最多的重灾区之一。但湖北省HFRS的流行特征尚不完全清楚，长期以来对该疫区的系统调查十分有限。方法利用1980 - 2009年HFRS疫情资料，分析HFRS的时空分布特征。计算1980 - 2009年HFRS年发病率、病死率和季节发病率并绘制成图。应用GIS技术对HFRS的空间分布和季节变化进行分析。空间统计分析，使用Kulldorff的空间扫描统计，进行识别HFRS的聚集。结果1980 - 2009年湖北省共报告HFRS病例104,467例。20世纪80年代暴发后，HFRS发病率和死亡率下降，近年来HFRS病例呈散发状态。在这三十年中，疾病群的位置和规模发生了变化。HFRS季节性流行模式由单峰型（秋冬高峰）向双峰型转变。结论湖北省社会经济发展对汉坦病毒的人传人有较大影响，并出现了新的流行特点。应根据新出现的季节变化，加强HFRS的预防工作，特别是在湖北省城市地区。
Background Hemorrhagic fever with renal syndrome (HFRS) is caused by different hantaviruses within the Bunyaviridae family. HFRS is a fulminant, infectious disease that occurs worldwide and is endemic in all 31 provinces of China. Since the first HFRS case in Hubei Province was reported in 1957, the disease has spread across the province and Hubei has become one of the seriously affected areas in China with the greatest number of reported HFRS cases in the 1980's. However, the epidemic characteristics of HFRS in Hubei are still not entirely clear and long-term, systematic investigations of this epidemic area have been very limited. Methods The spatiotemporal distribution of HFRS was investigated using data spanning the years 1980 to 2009. The annual HFRS incidence, fatality rate and seasonal incidence between 1980 and 2009 were calculated and plotted. GIS-based spatial analyses were conducted to detect the spatial distribution and seasonal pattern of HFRS. A spatial statistical analysis, using Kulldorff's spatial scan statistic, was performed to identify clustering of HFRS. Results A total of 104,467 HFRS cases were reported in Hubei Province between 1980 and 2009. Incidence of and mortality due to HFRS declined after the outbreak in 1980s and HFRS cases have been sporadic in recent years. The locations and scale of disease clusters have changed during the three decades. The seasonal epidemic pattern of HFRS was characterized by the shift from the unimodal type (autumn/winter peak) to the bimodal type. Conclusions Socioeconomic development has great influence on the transmission of hantaviruses to humans and new epidemic characteristics have emerged in Hubei Province. It is necessary to reinforce preventative measures against HFRS according to the newly-presented seasonal variation and to intensify these efforts especially in the urban areas of Hubei Province.
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影响因子：
0.8
作者：
Kulldorff, M
通讯作者：
Kulldorff, M
影响因子：
7.7
作者：
Bi, P;Tong, S;Ni, J
通讯作者：
Ni, J
影响因子：
6.4
作者：
CHEN, HX;QIU, FX;GAO, SY
通讯作者：
GAO, SY
影响因子：
3.7
作者：
Fang, Liqun;Yan, Lei;Liang, Song;de Vlas, Sake J.;Feng, Dan;Han, Xiaona;Zhao, Wenjuan;Xu, Bing;Bian, Ling;Yang, Hong;Gong, Peng;Richardus, Jan Hendrik;Cao, Wuchun
通讯作者：
Cao, Wuchun
影响因子：
2.5
作者：
KIM, YS;AHN, C;LEE, PW
通讯作者：
LEE, PW