Inactivation of the putamen selectively impairs reward history-based action selection.
Inactivation of the putamen selectively impairs reward history-based action selection.
复制标题
DOI：
10.1007/s00221-011-2545-y
复制
发表时间：
2011-03
影响因子：
2
通讯作者：
Kimura, Minoru
中科院分区：
文献类型：
--
作者：
Muranishi, Manabu;Inokawa, Hitoshi;Yamada, Hiroshi;Ueda, Yasumasa;Matsumoto, Naoyuki;Nakagawa, Masanori;Kimura, Minoru
行为决定和行动是为了实现特定的目标，获得奖励和逃避惩罚。以往有关神经元活动记录的研究表明，大脑皮层、基底神经节和中脑多巴胺系统参与了这些过程。行动选项的价值信号在纹状体中表示，通过奖励预测误差更新，并用于选择更高价值的行动。然而，纹状体功能障碍是否会导致基于价值的行为选择的损害尚不清楚。本研究考察了通过局部注射GABAA受体激动剂muscimol对参与手动奖励多步骤选择任务的猴子壳核失活的影响。猴子首先根据之前的一个或两个选择及其结果，从三个备选方案中搜索奖励目标，并获得较大的奖励；然后他们通过选择最后一个奖励目标获得额外奖励。在第三次试验中，壳核的失活损害了猴子做出最佳选择的能力。在第三次试验中，猴子被要求通过更新三个选项的值来选择一个不同于前两次试验中选择的目标。如果最后一个选择带来的奖励较少（输掉），猴子通常会改变选择；如果最后一个选择带来的奖励较多（赢掉），猴子通常会继续选择。壳核失活后，单个试验的任务开始时间和运动时间变长。但在壳核失活前后，猴子可以根据个体试验类型的奖励值来控制动机水平。这些结果支持了一种观点，即壳核选择性和批判性地参与了基于奖励历史的动作选择的神经元回路。
Behavioral decisions and actions are directed to achieve specific goals and to obtain rewards and escape punishments. Previous studies involving the recording of neuronal activity suggest the involvement of the cerebral cortex, basal ganglia, and midbrain dopamine system in these processes. The value signal of the action options is represented in the striatum, updated by reward prediction errors, and used for selecting higher-value actions. However, it remains unclear whether dysfunction of the striatum leads to impairment of value-based action selection. The present study examined the effect of inactivation of the putamen via local injection of the GABAA receptor agonist muscimol in monkeys engaged in a manual reward-based multi-step choice task. The monkeys first searched a reward target from three alternatives, based on the previous one or two choices and their outcomes, and obtained a large reward; they then earned an additional reward by choosing the last rewarded target. Inactivation of the putamen impaired the ability of monkeys to make optimal choices during third trial in which they were required to choose a target different from those selected in the two previous trials by updating the values of the three options. The monkeys normally changed options if the last choice resulted in small reward (lose-shift) and stayed with the last choice if it resulted in large reward (win-stay). Task start time and movement time during individual trials became longer after putamen inactivation. But monkeys could control the motivation level depending on the reward value of individual trial types before and after putamen inactivation. These results support a view that the putamen is involved selectively and critically in neuronal circuits for reward history-based action selection.
登录
查看更多内容
影响因子：
64.8
作者：
Daw, Nathaniel D.;O'Doherty, John P.;Dayan, Peter;Seymour, Ben;Dolan, Raymond J.
通讯作者：
Dolan, Raymond J.
影响因子：
3.3
作者：
Inokawa, H.;Yamada, H.;Kimura, M.
通讯作者：
Kimura, M.
DOI：
10.1098/rstb.1996.0129
发表时间：
1996-10-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
GoldmanRakic, PS
通讯作者：
GoldmanRakic, PS
影响因子：
3.2
作者：
Coull, Jennifer T.;Nazarian, Bruno;Vidal, Franck
通讯作者：
Vidal, Franck
影响因子：
56.9
作者：
Fiorillo, CD;Tobler, PN;Schultz, W
通讯作者：
Schultz, W