Different patterns of language activation in post-stroke aphasia are detected by overt and covert versions of the verb generation fMRI task.
Different patterns of language activation in post-stroke aphasia are detected by overt and covert versions of the verb generation fMRI task.
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DOI：
10.12659/msm.882518
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Szaflarski JP
中科院分区：
文献类型：
--
作者：
Allendorfer JB;Kissela BM;Holland SK;Szaflarski JP
中风后语言功能依赖于优势半球和非优势半球的相对贡献。因此，我们的目标是确定成人卒中后失语症中显性和隐性动词生成的神经关联。16名失语症LMCA卒中患者(SP)和32名健康对照(HCS)在执行显性事件相关动词生成任务(ER-VGT)和隐蔽区块设计动词生成任务(BD-VGT)的同时，接受了语言测试和功能磁共振检查。BD-VGT的激活模式与以前的研究一致，而ER-VGT在SPS和HC中表现出不同的激活模式，包括在语义加工过程中较少涉及左半球，而与发音和听觉加工有关的主要是右侧激活。ER-VGT内扫描仪的性能与语义关联期间的激活呈正相关，对于HCS(p=0.031)和对于SPS(p=0.042)的左额中回。额叶上回/扣带回的激活增加与更好的内部扫描仪性能相关(p=0.020)。病变大小对受控口语词汇联想测验(p=0.0092)和语义流利性测验(p=0.033)的言语流利性有负面影响，并与事件相关动词生成任务中的动词生成成绩呈负相关(p=0.081)。卒中前语言技能的较大保留与左半球的更多参与有关，在SPS和HCS中观察到不同的皮质招募模式。中风后的语言流畅性可能更多地取决于占主导地位的左半球语言网络的结构和功能的完整性，而不是转向对侧同源。
Post-stroke language functions depend on the relative contributions of the dominant and non-dominant hemispheres. Thus, we aimed to identify the neural correlates of overt and covert verb generation in adult post-stroke aphasia. Sixteen aphasic LMCA stroke patients (SPs) and 32 healthy controls (HCs) underwent language testing followed by fMRI while performing an overt event-related verb generation task (ER-VGT) isolating activations related to noun-verb semantic processing or to articulation and auditory processing, and a covert block design verb generation task (BD-VGT). BD-VGT activation patterns were consistent with previous studies, while ER-VGT showed different patterns in SPs relative to HCs including less left-hemispheric involvement during semantic processing and predominantly right-sided activation related to articulation and auditory processing. ER-VGT intra-scanner performance was positively associated with activation during semantic associations in the left middle temporal gyrus for HCs (p=0.031) and left middle frontal gyrus for SPs (p=0.042). Increased activation in superior frontal/cingulate gyri was associated with better intra-scanner performance (p=0.020). Lesion size negatively impacted verbal fluency tested with Controlled Oral Word Association Test (p=0.0092) and the Semantic Fluency Test (p=0.033) and trended towards a negative association with verb generation performance on the event-related verb generation task (p=0.081). Greater retention of pre-stroke language skills is associated with greater involvement of the left hemisphere with different cortical recruitment patterns observed in SPs versus HCs. Post-stroke verbal fluency may depend more upon the structural and functional integrity of the dominant left hemisphere language network rather than the shift to contralateral homologues.
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DOI：
10.1523/jneurosci.2227-10.2010
发表时间：
2010-09-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fridriksson J
通讯作者：
Fridriksson J
影响因子：
5.7
作者：
Holland, SK;Plante, E;Ball, WS
通讯作者：
Ball, WS
影响因子：
3.7
作者：
Fridriksson, Julius;Bonilha, Leonardo;Rorden, Chris
通讯作者：
Rorden, Chris
影响因子：
8.3
作者：
Baker JM;Rorden C;Fridriksson J
通讯作者：
Fridriksson J
影响因子：
14.5
作者：
DERENZI, E;VIGNOLO, LA
通讯作者：
VIGNOLO, LA