A Self-Powered Optogenetic System for Implantable Blood Glucose Control.
A Self-Powered Optogenetic System for Implantable Blood Glucose Control.
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用于植入式血糖控制的自供电光遗传学系统
DOI：
10.34133/2022/9864734
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发表时间：
2022
期刊：
影响因子：
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中科院分区：
文献类型：
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作者：
Diabetes treatment and rehabilitation are usually a lifetime process. Optogenetic engineered designer cell-therapy holds great promise in regulating blood glucose homeostasis. However, portable, sustainable, and long-term energy supplementation has previously presented a challenge for the use of optogenetic stimulation in vivo. Herein, we purpose a self-powered optogenetic system (SOS) for implantable blood glucose control. The SOS consists of a biocompatible far-red light (FRL) source, FRL-triggered transgene-expressing cells, a power management unit, and a flexible implantable piezoelectric nanogenerator (i-PENG) to supply long-term energy by converting biomechanical energy into electricity. Our results show that this system can harvest energy from body movement and power the FRL source, which then significantly enhanced production of a short variant of human glucagon-like peptide 1 (shGLP-1) in vitro and in vivo. Indeed, diabetic mice equipped with the SOS showed rapid restoration of blood glucose homeostasis, improved glucose, and insulin tolerance. Our results suggest that the SOS is sufficiently effective in self-powering the modulation of therapeutic outputs to control glucose homeostasis and, furthermore, present a new strategy for providing energy in optogenetic-based cell therapy.
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影响因子：
17.6
作者：
Li J;Kang L;Yu Y;Long Y;Jeffery JJ;Cai W;Wang X
通讯作者：
Wang X
影响因子：
13.9
作者：
Fenno L;Yizhar O;Deisseroth K
通讯作者：
Deisseroth K
DOI：
10.1038/nrendo.2011.77
发表时间：
2011-06-07
期刊：
Nature reviews. Endocrinology
影响因子：
--
作者：
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影响因子：
5.5
作者：
Li, Qi;Li, Zhou;Meng, Jianping
通讯作者：
Meng, Jianping
影响因子：
29.4
作者：
Hwang, Geon-Tae;Park, Hyewon;Lee, Keon Jae
通讯作者：
Lee, Keon Jae