Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys.
Individual differences in the effects of environmental stimuli on cocaine choice in socially housed male cynomolgus monkeys.
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DOI：
10.1007/s00213-011-2562-3
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发表时间：
2012-11
影响因子：
3.4
通讯作者：
Nader, Michael A.
中科院分区：
文献类型：
--
作者：
Czoty, Paul W.;Nader, Michael A.
对实验室动物的研究表明，环境产生的压力和富集对兴奋剂的强化作用有影响。描述急性暴露于行为学上有效的环境刺激对群体圈养猴中可卡因相对于食物的强化强度的影响。在以下操作后，立即在16只群居（4只/围栏）雄性食蟹猴的亚组中评估可卡因和食物之间的选择：（1）将零食放在家中;（2）暴露于橡胶蛇10分钟或（3）在没有笼友的较大环境中生活3至7天。在家庭笼中放置零食使5只受试猴子的可卡因剂量反应曲线向左移动，12只猴子中有4只向右移动。橡胶蛇显著地将占优势的猴子的可卡因选择曲线向左移动。暴露于扩大的环境中减少可卡因的选择在9 15只猴子，这种影响是短暂的，不相关的社会地位。重复测试并不影响可卡因的选择。短暂暴露于环境事件假设是压力源或丰富改变可卡因的选择，虽然不是所有的人都受到影响，影响是短暂的。重要的是，这些数据表明，在环境中实施积极的变化产生了临床上所需的效果。行为和神经生物学机制介导的敏感性环境事件的社会圈养的动物将导致更好的治疗策略的药物成瘾。
Studies in laboratory animals have demonstrated an influence of environmentally derived stress and enrichment on the reinforcing effects of stimulants. To characterize the effects of acute exposure to ethologically valid environmental stimuli on the reinforcing strength of cocaine relative to food in socially housed monkeys. Choice between cocaine and food was assessed in subsets of sixteen socially housed (4/pen) male cynomolgus monkeys immediately after the following manipulations: (1) treats placed in homecage; (2) a 10-minute exposure to a rubber snake or (3) three to seven days of living in a larger environment without cage mates. Placing treats in the homecage shifted the cocaine dose-response curve to the left in 5 monkeys tested and to the right in 4 of 12 animals. The rubber snake significantly shifted the cocaine choice curve to the left in dominant monkeys. Exposure to an enlarged environment decreased cocaine choice in 9 of 15 monkeys; this effect was transient and not related to social rank. Repeated testing did not affect cocaine choice. Brief exposure to environmental events hypothesized to be stressors or enrichment altered cocaine choice, although not all individuals were affected and the effects were transient. Importantly, the data suggest that implementing positive changes in the environment produced effects that are clinically desirable. The behavioral and neurobiological mechanisms mediating sensitivity to environmental events in socially housed animals will lead to better treatment strategies for drug addiction.
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影响因子：
1.6
作者：
DRAPER, WA;BERNSTEIN, IS
通讯作者：
BERNSTEIN, IS
影响因子：
3.2
作者：
Czoty PW;Gould RW;Nader MA
通讯作者：
Nader MA
影响因子：
3.7
作者：
Drgon T;Zhang PW;Johnson C;Walther D;Hess J;Nino M;Uhl GR
通讯作者：
Uhl GR
影响因子：
4.7
作者：
BOWLING, SL;ROWLETT, JK;BARDO, MT
通讯作者：
BARDO, MT
影响因子：
1.4
作者：
CROCKETT, CM;BOWERS, CL;SACKETT, GP
通讯作者：
SACKETT, GP