Mast Cells Contain Large Quantities of Secretagogue‐Sensitive N‐Acetylaspartate
Mast Cells Contain Large Quantities of Secretagogue‐Sensitive N‐Acetylaspartate
复制标题
肥大细胞含有大量促分泌素敏感的 N-乙酰天冬氨酸
作者：
A. Burlina;V. Ferrari;L. Facci;S. Skaper;A. Burlina
Abstract: Mast cells play a central role in both immediate allergic reactions and inflammation. A functional nerve‐mast cell interaction has been proposed, given the morphological association between mast cells and neuropeptide‐containing peripheral nerves. We now show that purified rat peritoneal mast cells contain large quantities of N‐acetylaspartate (NAA; 747.50 nmol/mg of protein). Mast cell levels of NAA were rapidly reduced, by 64.0 and 86.4%, following treatment with compound 48/80 and mastoparan, respectively. These secretagogues strongly decreased mast cell histamine content over the same time period, suggesting also that NAA is stored in secretory granules. The data are the first to show that NAA is present in an immune effector cell type. Because NAA may be involved in myelin synthesis and glutamyl peptide metabolism, NAA released from mast cells following nervous or other stimuli could participate in neuroimmune interactions. Mast cells in multiple sclerosis plaques may contribute to the reported elevations in brain NAA in this disease.
DOI：
10.1056/nejm199301283280408
发表时间：
1993-01
期刊：
The New England journal of medicine
影响因子：
--
作者：
S. Galli
通讯作者：
S. Galli
使用高分辨率 1H 磁共振波谱对大鼠突触体和大脑进行定量分析。
DOI：
10.1016/0009-8981(92)90014-h
发表时间：
1992
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Petroff,OA;Burlina,AP;Black,J;Prichard,JW
通讯作者：
Prichard,JW