Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study.
Protective effects of dietary carotenoids on risk of hip fracture in men: the Singapore Chinese Health Study.
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DOI：
10.1002/jbmr.2041
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发表时间：
2014-02
影响因子：
6.2
通讯作者：
Koh, Woon-Puay
中科院分区：
文献类型：
--
作者：
Dai, Zhaoli;Wang, Renwei;Ang, Li-Wei;Low, Yen-Ling;Yuan, Jian-Min;Koh, Woon-Puay
实验和流行病学数据表明，蔬菜和水果中的类胡萝卜素由于其抗氧化特性可能有益于骨骼健康。研究了新加坡华人膳食中总类胡萝卜素和特定类胡萝卜素以及蔬菜和水果与髋部骨折风险之间的关系。我们使用了来自新加坡华人健康研究的数据，这是一项前瞻性队列研究，包括1993年至1998年间年龄在45-74岁之间的63,257名男性和女性。在招募时，对受试者进行了生活方式因素和病史的访谈。使用经验证的食物频率问卷测量饮食。在平均9.9年的随访中，我们确定了1,630例髋部骨折事件。在男性中，蔬菜的消费与较低的髋部骨折风险有关。同样，膳食总类胡萝卜素和特定类胡萝卜素，α-，β-胡萝卜素和叶黄素/玉米黄质与髋部骨折风险呈负相关。与营养密度最低四分位数的男性相比，营养密度最高四分位数的男性风险降低了26%至39%，具有统计学意义（所有趋势P < 0.05）。当按体重指数分层时，总蔬菜和类胡萝卜素的最大保护作用出现在体重指数<20 kg/m2的男性中（趋势P ≤0.004）。饮食中的类胡萝卜素或蔬菜/水果与女性髋部骨折风险之间没有关联。这项研究表明，摄入足够的蔬菜可以降低老年男性骨质疏松性骨折的风险，类胡萝卜素的抗氧化作用可以抵消与瘦有关的骨质疏松症的机制。
Experimental and epidemiologic data suggest that carotenoids in vegetables and fruits may benefit bone health due to their antioxidant properties. The relationship between dietary total and specific carotenoids, as well as vegetables and fruits, and risk of hip fracture was examined among Chinese in Singapore. We used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women who were of ages 45–74 years between 1993 and 1998. At recruitment, subjects were interviewed on lifestyle factors and medical history. Usual diet was measured using a validated food frequency questionnaire. During a mean follow-up of 9.9 years, we identified 1,630 hip fracture incident cases. Among men, consumption of vegetables was associated with lower hip fracture risk. Similarly, dietary total carotenoids and specific carotenoids, α-, β-carotene and lutein/zeaxanthin were inversely associated with hip fracture risk. Compared to men in the lowest quartile of nutrient density, men in the highest quartile had statistically significant 26% to 39% risk reduction (all Ps for trend < 0.05). When stratified by body mass index, the greatest protective effects of total vegetables and carotenoids were found in men with body mass index < 20kg/m2 (P for trend≤0.004). There was no association between dietary carotenoids or vegetables/fruits and hip fracture risk among women. This study suggests that adequate intake of vegetables may reduce risk of osteoporotic fractures among elderly men and that the antioxidant effects of carotenoids may counteract the mechanism of osteoporosis related to leanness.
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影响因子：
4.2
作者：
DAWSONHUGHES, B;SHIPP, C;DALLAL, G
通讯作者：
DALLAL, G
DOI：
10.1016/s0735-1097(03)00630-2
发表时间：
2003-07-16
影响因子：
24
作者：
Higashi, Y;Sasaki, S;Yoshizumi, M
通讯作者：
Yoshizumi, M
影响因子：
4.2
作者：
Dy, Christopher J.;LaMont, Lauren E.;Lane, Joseph M.
通讯作者：
Lane, Joseph M.
影响因子：
4.2
作者：
Cawthon, Peggy M.
通讯作者：
Cawthon, Peggy M.
影响因子：
2.3
作者：
Endo, Y;Aharonoff, GB;Koval, KJ
通讯作者：
Koval, KJ