Clinical correlates of periodic limb movements in sleep in Parkinson's disease.
Clinical correlates of periodic limb movements in sleep in Parkinson's disease.
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DOI：
10.1016/j.jns.2012.01.004
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发表时间：
2012-05-15
影响因子：
4.4
通讯作者：
Ancoli-Israel, Sonia
中科院分区：
文献类型：
--
作者：
Covassin, Naima;Neikrug, Ariel B.;Liu, Lianqi;Corey-Bloom, Jody;Loredo, Jose S.;Palmer, Barton W.;Maglione, Jeanne;Ancoli-Israel, Sonia
关键词：
本研究旨在探讨帕金森病(PD)患者睡眠中周期性肢体运动(PLMS)的频率及其对夜间睡眠和白天功能的影响。45例帕金森病患者(平均年龄68.5±8.7岁，男性32例)进行了一晚多导睡眠图(PSG)监测。完成临床评估和问卷调查，评估睡眠障碍和生活质量。根据PLMS指数将患者分为两组：PLMSI≥15(PLMS+)组和PLMSI+15(PLMS−)组。PLMS+组26例(57.8%)，−组19例(42.2%)。主观评估显示，PLMS+状态与更严重的PD症状、更主观的睡眠障碍和降低的生活质量有关。所有患者都表现出睡眠不佳，在PSG测量上没有发现显著的组间差异。我们观察到PLMS在PD中频繁发生，并且随着PD的加重而增加。虽然PLMS不影响客观睡眠，但它与睡眠投诉增加和生活质量下降有关。总体而言，我们的发现支持PLMS与PD之间的联系，以及PD患者睡眠障碍的临床相关性。
The aim of the current study was to investigate the frequency of periodic limb movements in sleep (PLMS) in Parkinson’s disease (PD) and their impact on nocturnal sleep and daytime functioning. Forty-five PD patients (mean age 68.5±8.7 years; 32 males) underwent one night of polysomnography (PSG). Clinical assessment and questionnaires evaluating sleep disturbance and quality of life (QoL) were completed. Patients were divided into two groups based on their PLMS index (PLMSI): PLMSI ≥15 (PLMS+) and PLMSI <15 (PLMS−). There were 26 (57.8%) PD patients in the PLMS+ group and 19 (42.2%) patients in the PLMS− group. Subjective assessment revealed an association between PLMS+ status and greater PD symptom severity, more subjective sleep disturbance, and decreased QoL. All patients showed poor sleep, and no significant group differences were detected on PSG measures. We observed that PLMS occurred frequently in PD and increased with more severe PD. Although PLMS did not affect objective sleep, it was associated with increased sleep complaints and reduced QoL. Overall, our findings support the association between PLMS and PD as well as the clinical relevance of sleep disturbances in PD.
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影响因子：
11
作者：
Gjerstad, M. D.;Boeve, B.;Larsen, J. P.
通讯作者：
Larsen, J. P.
影响因子：
11.2
作者：
COLEMAN, RM;POLLAK, CP;WEITZMAN, ED
通讯作者：
WEITZMAN, ED
影响因子：
9.9
作者：
Gagnon, JF;Bédard, MA;Montplaisir, J
通讯作者：
Montplaisir, J
影响因子：
5.6
作者：
ANCOLIISRAEL, S;KRIPKE, DF;KAPLAN, O
通讯作者：
KAPLAN, O
影响因子：
8.6
作者：
Carrier, J;Frenette, S;Morettini, J
通讯作者：
Morettini, J