Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.
Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.
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缺乏β2-微球蛋白的HLA-B27转基因小鼠中的自发性炎症性关节炎：人脊椎炎的模型。
DOI：
10.1084/jem.182.4.1153
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发表时间：
1995-10-01
影响因子：
15.3
通讯作者：
David, Chella S.
中科院分区：
文献类型：
--
作者：
Khare, Sanjay D.;Luthra, Harvinder S.;David, Chella S.
Human class I major histocompatibility complex allele HLA-B27 is associated with a group of human diseases called "spondyloarthropathies." Studies on transgenic rats expressing HLA-B27 and human beta 2-microglobulin have confirmed the role of HLA-B27 in disease pathogenesis. Here we report spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin (B27+ beta 2m-/- ). In the absence of beta 2-microglobulin, B27+ beta 2m-/- animals do not express the HLA-B27 transgene on the cell surface and have a very low level of CD8+ T cells. Most of the B27+ beta 2m-/- male mice showed nail changes, hair loss, and swelling in paws, which leads to ankylosis. The symptoms occur only after the B27+ beta 2m-/- mice are transferred from the specific pathogen-free mouse colony. These results suggest that aberrant assembly, transport, and expression of the HLA- B27 molecule may predispose an individual for development of the disease when exposed to an appropriate environmental trigger.
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DOI：
10.1073/pnas.83.19.7447
发表时间：
1986-10-01
影响因子：
11.1
作者：
ALLEN, H;FRASER, J;FLAVELL, R
通讯作者：
FLAVELL, R
影响因子：
64.8
作者：
POWIS, SJ;DEVERSON, EV;HOWARD, JC
通讯作者：
HOWARD, JC
Beta 2-微球蛋白缺陷型小鼠中的CD8+ T细胞库有偏向于反应性。
影响因子：
15.3
作者：
Glas, R;Ohlen, C;Hoglund, P;Karre, K
通讯作者：
Karre, K
影响因子：
64.8
作者：
JARDETZKY, TS;LANE, WS;WILEY, DC
通讯作者：
WILEY, DC
影响因子：
64.5
作者：
HAMMER, RE;MAIKA, SD;TAUROG, JD
通讯作者：
TAUROG, JD