Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect.
Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect.
复制标题
DOI：
10.1016/j.neuroimage.2009.11.020
复制
发表时间：
2010-02-15
期刊：
影响因子：
5.7
通讯作者：
Rao, Hengyi
中科院分区：
文献类型：
--
作者：
Lim, Julian;Wu, Wen-chau;Wang, Jiongjiong;Detre, John A.;Dinges, David F.;Rao, Hengyi
在持续的繁重的认知工作量期间，人类通常会表现出任务时间效应（TOT），在任务参与期间，表现会逐渐变差。本研究采用动脉自旋标记（ASL）灌注功能磁共振成像（fMRI）研究了15名受试者在进行20分钟连续精神运动警觉性测试（PVT）时TOT效应的神经相关性。实验对象表现出明显的TOT效应，在任务完成后反应时间逐渐变慢，精神疲劳等级显著增加。灌注数据显示，除了基底节区和感觉运动皮质外，PVT还激活了右侧额顶叶注意网络。与任务前休息相比，任务后休息时额顶叶网络的活跃程度较低，该网络的区域CBF减少与表现下降相关。这些结果表明，在一段时间的繁重脑力工作后，认知疲劳对额顶叶网络的持续影响，并表明该注意网络在介导TOT效应中的关键作用。此外，在任务开始前，丘脑和右额中回的静息区域CBF可以预测受试者随后的表现下降，这表明ASL灌注功能磁共振成像量化的静息CBF可能是一个有用的表现潜力指标和神经注意系统疲劳水平的标志。
During sustained periods of a taxing cognitive workload, humans typically display time-on-task (TOT) effects, in which performance gets steadily worse over the period of task engagement. Arterial spin labeling (ASL) perfusion functional magnetic resonance imaging (fMRI) was used in this study to investigate the neural correlates of TOT effects in a group of 15 subjects as they performed a 20-minute continuous psychomotor vigilance test (PVT). Subjects displayed significant TOT effects, as seen in progressively slower reaction times and significantly increased mental fatigue ratings after the task. Perfusion data showed that the PVT activates a right lateralized fronto-parietal attentional network in addition to the basal ganglia and sensorimotor cortices. The fronto-parietal network was less active during post-task rest compared to pre-task rest, and regional CBF decrease in this network correlated with performance decline. These results demonstrate the persistent effects of cognitive fatigue in the fronto-parietal network after a period of heavy mental work and indicate the critical role of this attentional network in mediating TOT effects. Furthermore, resting regional CBF in the thalamus and right middle frontal gyrus prior to task onset was predictive of subjects' subsequent performance decline, suggesting that resting CBF quantified by ASL perfusion fMRI may be a useful indicator of performance potential and a marker of the level of fatigue in the neural attentional system.
登录
查看更多内容
影响因子：
22.4
作者：
FRANKMANN, JP;ADAMS, JA
通讯作者：
ADAMS, JA
DOI：
10.1152/ajpregu.00197.2002
发表时间：
2003-02-01
影响因子：
2.8
作者：
Leproult, R;Colecchia, EF;Van Cauter, E
通讯作者：
Van Cauter, E
影响因子：
5.7
作者：
Foucher, JR;Otzenberger, H;Gounot, D
通讯作者：
Gounot, D
影响因子：
158.5
作者：
Landrigan, CP;Rothschild, JM;Czeisler, CA
通讯作者：
Czeisler, CA
影响因子：
1.9
作者：
Caldwell, JA;Mu, QW;George, MS
通讯作者：
George, MS