Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice.
Regulatory mechanisms in immune responses to heterologous insulins. II. Suppressor T cell activation associated with nonresponsiveness in H-2b mice.
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DOI：
10.1084/jem.160.4.1012
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发表时间：
1984-10-01
期刊：
影响因子：
--
通讯作者：
Kapp JA
中科院分区：
文献类型：
--
作者：
Jensen PE;Pierce CW;Kapp JA
Murine antibody responses to insulins are controlled by MHC-linked Ir genes. Although mice of the H-2b haplotype do not make antibody in response to pork insulin, we demonstrate in this communication that immunization with pork insulin stimulates radioresistant, Lyt-1+2- helper T cells that are capable of stimulating secondary antibody responses to pork insulin in vitro, but that this activity is masked by radiosensitive, Lyt-1-2+, I-J+ suppressor T cells. The suppressor T cells, present after immunization with pork insulin but not beef insulin, suppress the secondary response to pork but not beef insulin. The amino acid sequences of pork and beef insulins differ only at the A- chain loop; thus, pork insulin-specific suppressor T cells appear to recognize the A-chain loop determinant of pork insulin. The amino acid sequences of mouse and pork insulin are identical in the A-chain loop, which suggests that these suppressor T cells may be self-reactive. If this interpretation is correct, these suppressor T cells could be involved in the maintenance of self-tolerance to insulin. Nevertheless, these data clearly demonstrate that genetically determined nonresponsiveness in H-2b mice is conferred by activation of dominant, insulin-specific suppressor T cells (Ts), rather than by a defect in the stimulation of insulin-specific helper T cells (Th).
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影响因子：
15.3
作者：
Kapp, J A;Pierce, C W;Schlossman, S;Benacerraf, B
通讯作者：
Benacerraf, B
体外免疫反应的遗传控制。 I.在体外，小鼠脾细胞在体外开发了对随机晶状体1-谷氨酸60-1-丙氨酸30-1-丙氨酸30-1-丙氨酸10（GAT）的原发性和继发斑块形成细胞的反应。
DOI：
10.1084/jem.138.5.1107
发表时间：
1973-11-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kapp JA;Pierce CW;Benacerraf B
通讯作者：
Benacerraf B
影响因子：
15.3
作者：
IMANISHI, T;MAKELA, O
通讯作者：
MAKELA, O
影响因子：
64.8
作者：
KECK, K
通讯作者：
KECK, K
影响因子：
15.3
作者：
PIERCE, CW;JOHNSON, BM;ASOFSKY, R
通讯作者：
ASOFSKY, R