Protecting the skin-implant interface with transcutaneous silver-coated skin-and-bone-integrated pylon in pig and rabbit dorsum models.
Protecting the skin-implant interface with transcutaneous silver-coated skin-and-bone-integrated pylon in pig and rabbit dorsum models.
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DOI：
10.1002/jbm.b.34725
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发表时间：
2021-04
影响因子：
3.4
通讯作者：
Pitkin, Mark
中科院分区：
文献类型：
--
作者：
Shevtsov, Maxim;Gavrilov, Dmitriy;Yudintceva, Natalia;Zemtsova, Elena;Arbenin, Andrei;Smirnov, Vladimir;Voronkina, Irina;Adamova, Polina;Blinova, Miralda;Mikhailova, Nataliya;Galibin, Oleg;Akkaoui, Michael;Pitkin, Mark
皮肤-植入物界面处的植入物相关软组织感染是重建手术中最常见的并发症，并导致植入物失效和翻修。具有深孔隙度的钛植入物，称为皮肤和骨整合的支架（SBIP），允许皮肤在形态上自然的方向向内生长，从而恢复可靠的真皮屏障并降低感染的风险。使用物理气相沉积技术对SBIP植入物表面进行银涂层，可防止生物膜形成，并在伤口愈合阶段发挥直接的抗菌作用。采用猪和兔背部模型评估皮肤长入支架孔隙的体内研究证明了SBIP系统经皮植入的安全性。在6个月随访期结束时，未报告术后并发症。组织学分析证明在小型猪模型中皮肤向内生长，没有银毒性的迹象。在新西兰兔骨髓内插入的银涂层SBIP模型中的银释放分析（使用能量色散X射线光谱法）证实了骨内植入3个月后的痕量银。总之，SBIP植入物表面选择的临时银涂层在预防假体周围感染方面效果显著，且不影响皮肤向内生长，可考虑用于临床应用。
Implant-associated soft tissue infections at the skin-implant interface represent the most frequent complications in reconstructive surgery and lead to implant failures and revisions. Titanium implants with deep porosity, called skin-and-bone-integrated-pylons (SBIP), allow for skin ingrowth in the morphologically natural direction, thus restoring a reliable dermal barrier and reducing the risk of infection. Silver coating of the SBIP implant surface using physical vapor deposition technique offers the possibility of preventing biofilm formation and exerting a direct antimicrobial effect during the wound healing phase. In vivo studies employing pig and rabbit dorsum models for assessment of skin ingrowth into the pores of the pylon demonstrated the safety of transcutaneous implantation of the SBIP system. No postoperative complications were reported at the end of the follow-up period of 6 months. Histological analysis proved skin ingrowth in the minipig model without signs of silver toxicity. Analysis of silver release (using energy dispersive X-ray spectroscopy) in the model of intramedullary-inserted silver-coated SBIP in New Zealand rabbits demonstrated trace amounts of silver after 3 months of in-bone implantation. In conclusion, selected temporary silver coating of the SBIP implant surface is powerful at preventing the periprosthetic infections without imparing skin ingrowth and can be considered for clinical application.
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影响因子：
1.5
作者：
Hagberg, K;Häggström, E;Brånemark, R
通讯作者：
Brånemark, R
影响因子：
--
作者：
Gerzina, Christopher;Potter, Eric;Dabash, Sherif
通讯作者：
Dabash, Sherif
影响因子：
2.4
作者：
Jarrell, Joshua R.;Farrell, Brad J.;Prilutsky, Boris, I
通讯作者：
Prilutsky, Boris, I
影响因子：
4.9
作者：
Kuehl, Richard;Brunetto, Priscilla S.;Khanna, Nina
通讯作者：
Khanna, Nina
DOI：
10.1016/j.clinbiomech.2013.12.014
发表时间：
2014-03
期刊：
Clinical biomechanics (Bristol, Avon)
影响因子：
--
作者：
Farrell BJ;Prilutsky BI;Kistenberg RS;Dalton JF 4th;Pitkin M
通讯作者：
Pitkin M