Impaired Cerebrovascular Reactivity in Huntington's Disease.
Impaired Cerebrovascular Reactivity in Huntington's Disease.
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DOI：
10.3389/fphys.2021.663898
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发表时间：
2021
影响因子：
4
通讯作者：
Rosas HD
中科院分区：
文献类型：
--
作者：
Chan ST;Mercaldo ND;Kwong KK;Hersch SM;Rosas HD
越来越多的证据表明，脑血管功能受损和/或脑血管异常可能是亨廷顿病(HD)早期神经细胞丢失的原因之一。对健康人和其他神经退行性疾病患者的研究使用了外源性二氧化碳(CO2)挑战结合功能磁共振成像(FMRI)来评估局部脑血管反应性(CVR)。在这项研究中，我们探讨了HD患者CVR的潜在损害。12名基因扩张型HD患者，包括症状前和症状早期的HD患者和11名健康对照，接受了一种混合气体，目标是相对于静息时呼气末二氧化碳分压(PETCO2)增加4-8毫米汞。使用希尔伯特变换分析计算区域BOLD信号变化时间序列(ΔBOLD)与PETCO2增加之间的互相关，并估计ΔBOLD相对于PETCO2的响应延迟。在对年龄进行校正后，我们发现HD受试者在几个皮质下白质区域的ΔBOLD和PETCO2的时间序列之间的交叉相关性比对照组更弱，这些白质区域包括穹隆体区、邻近扣带前和尾侧前部的皮质下白质、额叶中段和尾侧、额叶中段、岛状、颞中和扣带回后部。此外，观察到扩张的血管周围间隙(PVS)体积较大，主要沿着周围，与Δ反应延迟较大的区域重叠。我们的初步研究结果支持HD患者脑血管功能的改变，可能是HD早期神经病理的一个重要因素，但尚未被考虑。
There is increasing evidence that impairments of cerebrovascular function and/or abnormalities of the cerebral vasculature might contribute to early neuronal cell loss in Huntington’s disease (HD). Studies in both healthy individuals as well as in patients with other neurodegenerative disorders have used an exogenous carbon dioxide (CO2) challenge in conjunction with functional magnetic resonance imaging (fMRI) to assess regional cerebrovascular reactivity (CVR). In this study, we explored potential impairments of CVR in HD. Twelve gene expanded HD individuals, including both pre-symptomatic and early symptomatic HD and eleven healthy controls were administered a gas mixture targeting a 4–8 mmHg increase in CO2 relative to the end-tidal partial pressure of CO2 (PETCO2) at rest. A Hilbert Transform analysis was used to compute the cross-correlation between the time series of regional BOLD signal changes (ΔBOLD) and increased PETCO2, and to estimate the response delay of ΔBOLD relative to PETCO2. After correcting for age, we found that the cross-correlation between the time series for regional ΔBOLD and for PETCO2 was weaker in HD subjects than in controls in several subcortical white matter regions, including the corpus callosum, subcortical white matter adjacent to rostral and caudal anterior cingulate, rostral and caudal middle frontal, insular, middle temporal, and posterior cingulate areas. In addition, greater volume of dilated perivascular space (PVS) was observed to overlap, primarily along the periphery, with the areas that showed greater ΔBOLD response delay. Our preliminary findings support that alterations in cerebrovascular function occur in HD and may be an important, not as yet considered, contributor to early neuropathology in HD.
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影响因子：
8.8
作者：
Lim RG;Quan C;Reyes-Ortiz AM;Lutz SE;Kedaigle AJ;Gipson TA;Wu J;Vatine GD;Stocksdale J;Casale MS;Svendsen CN;Fraenkel E;Housman DE;Agalliu D;Thompson LM
通讯作者：
Thompson LM
影响因子：
3.3
作者：
McKay, LC;Evans, KC;Corfield, DR
通讯作者：
Corfield, DR
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
1.9
作者：
Liu Q;Li C;Wanga V;Shepherd BE
通讯作者：
Shepherd BE
影响因子：
8.3
作者：
Marstrand, JR;Garde, E;Larsson, HBW
通讯作者：
Larsson, HBW