Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells.
Smenospongine, a sesquiterpene aminoquinone from a marine sponge, induces G1 arrest or apoptosis in different leukemia cells.
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Smenospongine是一种来自海洋海绵的倍苯二酚氨基喹酮，可在不同的白血病细胞中诱导G1停滞或凋亡。
DOI：
10.3390/md20080023
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发表时间：
2008
期刊：
影响因子：
5.4
通讯作者：
Kobayashi M
中科院分区：
文献类型：
--
作者：
Kong D;Aoki S;Sowa Y;Sakai T;Kobayashi M
Smenospongine是一种从海绵Dacquillusspongiaelegans中分离得到的倍半萜氨基醌，它能诱导K562细胞向红系分化，并使其发生G1期阻滞。在这项研究中，我们研究了smenopongine对其他白血病细胞，包括HL 60人急性早幼粒细胞白血病细胞和U937人组织细胞淋巴瘤细胞的细胞周期的影响，通过流式细胞术分析。参松碱诱导HL 60和U937细胞凋亡呈剂量依赖性。Smenopongine处理后K562细胞p21表达增加，Rb磷酸化水平降低，提示p21-Rb通路在K562细胞G1期阻滞中起重要作用。然而，基于使用转染的K562细胞的荧光素酶测定，p21启动子未被smenospongine处理激活。海萝海绵碱可能通过另一种机制诱导p21表达，而不是通过p21启动子的反式激活。
Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other leukemia cells, including HL60 human acute promyelocytic leukemia cells and U937 human histiocytic lymphoma cells by flow cytometric analysis. Smenospongine induced apoptosis dose-dependently in HL60 and U937 cells. The smenospongine treatment increased expression of p21 and inhibited phosphorylation of Rb in K562 cells, suggesting the p21-Rb pathway play an important role in G1 arrest in K562 cells. However, the p21 promoter was not activated by the smenospongine treatment based on a luciferase assay using the transfected K562 cells. Smenospongine might induce p21 expression via another mechanism than transactivation of p21 promoter.
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影响因子：
2.3
作者：
Aoki, S;Kong, D;Kobayashi, M
通讯作者：
Kobayashi, M
影响因子：
20.3
作者：
LOZZIO, CB;LOZZIO, BB
通讯作者：
LOZZIO, BB
DOI：
10.1006/bbrc.2001.4588
发表时间：
2001-03-30
影响因子：
3.1
作者：
Aoki, S;Higuchi, K;Kobayashi, M
通讯作者：
Kobayashi, M
影响因子：
5.8
作者：
Sasakawa, Y;Naoe, Y;Mutoh, S
通讯作者：
Mutoh, S
影响因子：
64.8
作者：
DEKLEIN, A;VANKESSEL, AG;STEPHENSON, JR
通讯作者：
STEPHENSON, JR