Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome.
Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome.
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DOI：
10.1371/journal.pone.0241205
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Maruyama H
中科院分区：
文献类型：
--
作者：
Nakamori M;Hosomi N;Nishi H;Aoki S;Nezu T;Shiga Y;Kinoshita N;Ishikawa K;Imamura E;Shintani T;Ohge H;Kawaguchi H;Kurihara H;Wakabayashi S;Maruyama H
为了评估牙周病对脑出血及其临床过程的影响，我们研究了牙周病原体血清IgG滴度与出血增长和3个月预后的关系。我们连续收集了115例急性脑出血患者（44例女性，年龄71.3 ± 13.1岁），采用ELISA法检测了9种牙周致病菌：牙龈卟啉单胞菌、A.伴放线菌、中间普雷沃菌、变黑普雷沃菌、梭杆菌（F.）具核密螺旋体、齿垢密螺旋体（Treponema denticola）、坦纳氏菌（Tannerella）、直弯曲杆菌（Campylobacter rectus）和腐蚀艾肯氏菌（Eikenella corrodens）。显著血肿生长定义为体积增加>33%或体积绝对增加>12.5 mL。不良结局定义为改良兰金量表3分或以上。我们观察到13例患者（11.3%）出血增长。多因素分析显示，A.伴放线菌独立预测出血增长（优势比5.26，95%可信区间1.52-18.25，p = 0.01）。值得注意的是，F. nucleatum而不是A.伴放线菌感染导致3个月预后较差（比值比7.86，95%可信区间1.08-57.08，p = 0.04）。因此，我们证明了A.伴放线菌感染是预测脑出血病情发展独立因素，伴放线菌感染者血清IgG滴度高。核质可能预示着这种疾病患者的预后不良。总之，这些新的数据揭示了系统性牙周病原体如何影响中风患者，因此，在这些个体的管理和治疗中应予以考虑。
To assess the influence of periodontal disease on cerebral hemorrhage and its clinical course, we examined the association of the serum IgG titer of periodontal pathogens with hemorrhage growth and 3-month outcome. We consecutively enrolled 115 patients with acute cerebral hemorrhage (44 females, aged 71.3 ± 13.1 years) and used ELISA to evaluate the serum IgG titers of 9 periodontal pathogens: Porphyromonas gingivalis, Aggregatibacter (A.) actinomycetemcomitans, Prevotella intermedia, Prevotella nigrescens, Fusobacterium (F.) nucleatum, Treponema denticola, Tannerella forsythensis, Campylobacter rectus, and Eikenella corrodens. Significant hematoma growth was defined as an increase in the volume of >33% or an absolute increase in the volume of >12.5 mL. A poor outcome was defined as a 3 or higher on the modified Rankin Scale. We observed hemorrhage growth in 13 patients (11.3%). Multivariate analysis revealed that increased IgG titers of A. actinomycetemcomitans independently predicted the elevated hemorrhage growth (odds ratio 5.26, 95% confidence interval 1.52–18.25, p = 0.01). Notably, augmented IgG titers of F. nucleatum but not A. actinomycetemcomitans led to a poorer 3-month outcome (odds ratio 7.86, 95% confidence interval 1.08–57.08, p = 0.04). Thus, we demonstrate that elevated serum IgG titers of A. actinomycetemcomitans are an independent factor for predicting cerebral hemorrhage growth and that high serum IgG titers of F. nucleatum may predict a poor outcome in patients with this disease. Together, these novel data reveal how systemic periodontal pathogens may affect stroke patients, and, should, therefore, be taken into consideration in the management and treatment of these individuals.
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影响因子：
5.4
作者：
Han YW
通讯作者：
Han YW
DOI：
10.1016/j.jalz.2011.04.006
发表时间：
2012-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
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作者：
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影响因子：
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影响因子：
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