Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History.
Pial Vessel-Associated Microglia/Macrophages Increase in Female Dahl-SS/Jr Rats Independent of Pregnancy History.
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与妊娠史无关的女性DAHL-SS/JR大鼠的小血管相关小胶质细胞/巨噬细胞增加。
DOI：
10.3390/ijms23063384
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发表时间：
2022-03-21
影响因子：
5.6
通讯作者：
Sasser JM
中科院分区：
文献类型：
--
作者：
Warrington JP;Shao Q;Clayton AM;Maeda KJ;Beckett AG;Garrett MR;Sasser JM
作为中枢神经系统的常驻免疫细胞，小胶质细胞具有广泛的功能，例如监视、吞噬以及通过产生趋化因子和细胞因子来进行信号传导。最近的研究已经确定和表征了位于脑膜的巨噬细胞，脑膜是围绕大脑和脊髓的一系列层。虽然慢性高血压后脑实质内血管周围小胶质细胞增加，但没有脑膜变化的报告，特别是与软脑膜血管系统相关的变化。因此，我们使用雌性Sprague道利和Dahl盐敏感（SS/Jr）大鼠脑，对离子化钙结合接头分子（Iba 1）进行染色，并表征与后脑软脑膜血管相关的小胶质细胞/巨噬细胞。结果表明，Iba 1+软膜血管相关小胶质细胞（PVAM）完全包围Dahl-SS/Jr大鼠脑中的血管。与Sprague道利大鼠脑相比，Dahl-SS/Jr中的PVAM密度显著更高，PVAM之间的距离更低。妊娠史不影响这些结果。虽然这些细胞的功能作用尚不清楚，我们将我们的新发现与其他评估或表征中枢神经系统（脑膜和脉络丛）和血管周围巨噬细胞边界的骨髓细胞的研究联系起来，并提出它们可能起源于Dahl-SS/Jr慢性高血压模型。
As the resident immune cells of the central nervous system, microglia have a wide range of functions such as surveillance, phagocytosis, and signaling through production of chemokines and cytokines. Recent studies have identified and characterized macrophages residing at the meninges, a series of layers surrounding the brain and spinal cord. While perivascular microglia within the brain parenchyma increase following chronic hypertension, there are no reports of changes at the meninges, and specifically, associated with the pial vasculature. Thus, we used female Sprague Dawley and Dahl salt-sensitive (SS/Jr) rat brains, stained for ionized calcium-binding adapter molecule (Iba1), and characterized microglia/macrophages associated with pial vessels in the posterior brain. Results indicate that Iba1+ pial vessel-associated microglia (PVAM) completely surrounded the vessels in brains from the Dahl-SS/Jr rats. PVAM density was significantly higher and distance between PVAMs lower in Dahl-SS/Jr compared to the Sprague Dawley rat brains. Pregnancy history did not affect these findings. While the functional role of these cells are not known, we contextualize our novel findings with that of other studies assessing or characterizing myeloid cells at the borders of the CNS (meninges and choroid plexus) and perivascular macrophages and propose their possible origin in the Dahl-SS/Jr model of chronic hypertension.
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耦合的增殖和凋亡维持成人大脑中小胶质细胞的快速离职。
影响因子：
8.8
作者：
Askew K;Li K;Olmos-Alonso A;Garcia-Moreno F;Liang Y;Richardson P;Tipton T;Chapman MA;Riecken K;Beccari S;Sierra A;Molnár Z;Cragg MS;Garaschuk O;Perry VH;Gomez-Nicola D
通讯作者：
Gomez-Nicola D
影响因子：
56.9
作者：
Nimmerjahn, A;Kirchhoff, F;Helmchen, F
通讯作者：
Helmchen, F
DOI：
10.1016/j.bbi.2018.03.028
发表时间：
2018-05
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Clayton AM;Shao Q;Paauw ND;Giambrone AB;Granger JP;Warrington JP
通讯作者：
Warrington JP
影响因子：
8.3
作者：
Hung SK;Lee MS;Lin HY;Chen LC;Chuang CJ;Chew CH;Yu BH;Yang HJ;Hsu FC;Chiou WY
通讯作者：
Chiou WY
DOI：
10.1016/s0169-328x(98)00040-0
发表时间：
1998-06-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Ito, D;Imai, Y;Kohsaka, S
通讯作者：
Kohsaka, S