Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution.

Plasmid- and chromosome-encoded siderophore anguibactin systems found in marine vibrios: biosynthesis, transport and evolution.
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DOI:
10.1007/s10534-013-9629-z
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发表时间:
2013-08
期刊:
影响因子:
3.5
通讯作者:
Crosa, Jorge H.
Crosa, Jorge H.
中科院分区:
生物学3区
文献类型:
--
作者:
Naka, Hiroaki;Liu, Moqing;Actis, Luis A.;Crosa, Jorge H.

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鳗弧菌是一种海洋病原体,可引起弧菌病,这是一种水生无脊椎动物和脊椎动物的出血性败血症。铁载体安吉巴汀系统是该细菌最重要的毒力因子之一。大多数安吉巴汀生物合成和转运基因位于 65 kb pJM1 毒力质粒中,尽管其中一些基因存在于这种鱼类病原体的染色体中。 30 多年的研究揭示了众多染色体和 pJM1 基因在安吉巴汀合成以及同源铁复合物转运到细菌细胞中所发挥的作用。此外,这些研究表明,携带 pJM1 的菌株可能起源于产生染色体介导的铁载体 vanchrobactin 的无 pJM1 菌株。此外,我们最近在 V. harveyi 中发现了染色体介导的 anguibactin 系统,这表明 V. anguillarum anguibactin 系统可能的进化起源。在这篇综述中,我们提出了我们目前对这些致病弧菌中可能发生的安吉巴汀系统的机制和进化假设的理解。
Vibrio anguillarum is a marine pathogen that causes vibriosis, a hemorrhagic septicemia in aquatic invertebrate as well as vertebrate animals. The siderophore anguibactin system is one of the most important virulence factors of this bacterium. Most of the anguibactin biosynthesis and transport genes are located in the 65-kb pJM1 virulence plasmid although some of them are found in the chromosome of this fish pathogen. Over 30 years of research unveiled the role numerous chromosomal and pJM1 genes play in the synthesis of anguibactin and the transport of cognate ferric complexes into the bacterial cell. Furthermore, these studies showed that pJM1-carrying strains might be originated from pJM1-less strains producing the chromosome-mediated siderophore vanchrobactin. Additionally, we recently identified a chromosome-mediated anguibactin system in V. harveyi suggesting the possible evolutional origin of the V. anguillarum anguibactin system. In this review, we present our current understanding of the mechanisms and evolution hypothesis of the anguibactin system that might have occurred in these pathogenic vibrios.
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