Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.

Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.
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DOI:
10.1080/09500340.2012.687464
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发表时间:
2012-06-20
影响因子:
1.3
通讯作者:
Yao XC
Yao XC
中科院分区:
物理与天体物理4区
文献类型:
--
作者:
Li YC;Luo JM;Lu RW;Liu KM;Levy AM;Yao XC

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Dynamic monitoring of stimulus-evoked inner neural response is important for functional validation of stimulation protocols of retinal prosthetic devices. In this paper, we demonstrate label-free intrinsic optical signal (IOS) imaging of electrically stimulated inner neural response in freshly isolated mouse retinas. While single-pulse stimulation evoked rapid IOS within 20 ms, pulse-train stimulation indicated that the fast IOS response can follow frequency stimulation up to at least 8 Hz. Fast IOS imaging promises a noninvasive method for high resolution examination of electrically evoked retinal response, without artifact contamination of electrical stimulus.
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