Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.
Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse.
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DOI：
10.1016/j.bbr.2010.05.009
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发表时间：
2010-12-01
影响因子：
2.7
通讯作者：
Wood, Ruth I.
中科院分区：
文献类型：
--
作者：
Gorton, Lori M.;Vuckovic, Marta G.;Vertelkina, Nina;Petzinger, Giselle M.;Jakowec, Michael W.;Wood, Ruth I.
本研究使用1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）在小鼠中测定运动是否改善行为和多巴胺（DA）和5-羟色胺（5-HT）含量。雄性C57 BL/6小鼠接受MPTP（4×20 mg/kg）或生理盐水。6周后，每组8例，均保持久坐或踏车或自行跑轮锻炼。生理盐水处理的小鼠在转轮上跑得（22.8±1.0 m/min）明显快于在跑步机上跑（8.5±0.5 m/min），MPTP损伤并没有减少自主运动（19.3±1.5 m/min，p>0.05）。损伤和运动对整体旋转棒性能（ORF）有显着影响：与久坐小鼠相比，MPTP损伤降低了ORF，而跑步机运动增加了ORF（p<0.05）。MPTP增加了埋藏大理石实验中的焦虑：久坐不动的损伤组小鼠埋藏大理石的比例（74.0±5.2%）高于久坐不动的对照组（34.8± 11.8%，p<0.05）。相反，运动可以减少高架十字迷宫中的焦虑。在盐水处理的小鼠中，暴露于自愿轮跑的小鼠显示相对于相对于久坐对照组（36.2± 4.0%，p <0.05）的开放臂进入百分比增加（49.8± 3.5%，p<0.05）。MPTP和运动都没有改变蔗糖偏好或尾部悬吊测量的抑郁症状。MPTP显著降低纹状体中的DA（在久坐不动的损伤小鼠中为生理盐水对照的42.1±3.0%），并降低杏仁核和纹状体中的5 HT（在久坐不动的损伤小鼠中分别为生理盐水对照的86.1±4.1%和66.5±8.2%）;运动没有影响。因此，运动可以改善DA耗竭模型中的行为，而不会改变DA或5 HT。
This study used 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP) in mice to determine if exercise improves behavior and dopamine (DA) and serotonin (5HT) content. Male C57BL/6 mice received MPTP (4×20 mg/kg) or saline. They remained sedentary or exercised by treadmill or voluntary running wheel for 6 weeks (n=8/group). Saline-treated mice ran significantly faster on running wheels (22.8±1.0 m/min) than on treadmill (8.5±0.5 m/min), and MPTP lesion did not reduce voluntary exercise (19.3±1.5 m/min, p>0.05). There was a significant effect of both lesion and exercise on overall Rotarod performance (ORP): MPTP lesion reduced ORP, while treadmill exercise increased ORP vs sedentary mice (p<0.05). MPTP increased anxiety in the marble-burying test: sedentary lesioned mice buried more marbles (74.0±5.2%) than sedentary controls (34.8±11.8%, p<0.05). Conversely, exercise reduced anxiety on the elevated plus maze. Among saline-treated mice, those exposed to voluntary wheel-running showed an increased percent of open arm entries (49.8±3.5%, p<0.05) relative to relative to sedentary controls (36.2±4.0%, p<0.05). Neither MPTP nor exercise altered symptoms of depression measured by sucrose preference or tail suspension. MPTP significantly reduced DA in striatum (in sedentary lesioned mice to 42.1±3.0% of saline controls), and lowered 5HT in amygdala and striatum (in sedentary lesioned mice to 86.1±4.1% and 66.5±8.2% of saline controls, respectively); exercise had no effect. Thus, exercise improves behavior in a model of DA depletion, without changes in DA or 5HT.
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