Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.
Longitudinal characterization of behavioral, morphological and transcriptomic changes in a tauopathy mouse model.
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DOI：
10.18632/aging.205057
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发表时间：
2023-11-03
期刊：
影响因子：
5.2
通讯作者：
Yan, Zhen
中科院分区：
文献类型：
--
作者：
Cao, Qing;Kumar, Manasa;Frazier, Allea;Williams, Jamal B.;Zhao, Shengkai;Yan, Zhen
Neurodegenerative disorders, such as Alzheimer’s disease (AD), have the gradual onset of neurobiological changes preceding clinical diagnosis by decades. To elucidate how brain dysfunction proceeds in neurodegenerative disorders, we performed longitudinal characterization of behavioral, morphological, and transcriptomic changes in a tauopathy mouse model, P301S transgenic mice. P301S mice exhibited cognitive deficits as early as 3 months old, and deficits in social preference and social cognition at 5–6 months. They had a significant decrease of arborization in basal dendrites of hippocampal pyramidal neurons from 3 months and apical dendrites of PFC pyramidal neurons at 9 months. Transcriptomic analysis of genome-wide changes revealed the enrichment of synaptic gene upregulation at 3 months of age, while most of these synaptic genes were downregulated in PFC and hippocampus of P301S mice at 9 months. These time-dependent changes in gene expression may lead to progressive alterations of neuronal structure and function, resulting in the manifestation of behavioral symptoms in tauopathies.
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DOI：
10.1074/jbc.ra120.015882
发表时间：
2020-12-25
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Drepper F;Biernat J;Kaniyappan S;Meyer HE;Mandelkow EM;Warscheid B;Mandelkow E
通讯作者：
Mandelkow E
影响因子：
13.6
作者：
Cao Q;Wang W;Williams JB;Yang F;Wang ZJ;Yan Z
通讯作者：
Yan Z
影响因子：
34.7
作者：
Morrison, John H.;Baxter, Mark G.
通讯作者：
Baxter, Mark G.
影响因子：
3.7
作者：
Davis KE;Fox S;Gigg J
通讯作者：
Gigg J
影响因子：
3.8
作者：
Bicks LK;Koike H;Akbarian S;Morishita H
通讯作者：
Morishita H