Periconceptional nutrient intakes and risks of conotruncal heart defects.
Periconceptional nutrient intakes and risks of conotruncal heart defects.
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DOI：
10.1002/bdra.20648
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发表时间：
2010-03
影响因子：
--
通讯作者：
Lammer, Edward J.
中科院分区：
文献类型：
--
作者：
Shaw, Gary M.;Carmichael, Suzan L.;Yang, Wei;Lammer, Edward J.
有证据表明，母亲在怀孕早期使用维生素和叶酸补充剂与降低后代圆锥动脉干心脏缺陷风险之间存在关联。除了叶酸外，很少有关于围产期营养与心脏缺陷风险的调查。数据来源于1999年7月至2004年6月期间对加州一组出生的胎儿和活产婴儿进行的基于人群的病例对照研究。总共有76%的合格病例母亲和77%的合格对照母亲接受了采访。其中d型大动脉转位（dTGA）140例，法洛四联症（TOF）163例。对照组总数为698例。自我报告的维生素使用问卷调查围怀孕期，膳食营养素摄入量是由一个众所周知的食物频率问卷调查。dTGA与补充维生素使用相关的比值比为1.0（95%置信区间，0.7-1.5），TOF为0.9（0.6-1.3）。我们观察到与较低的亚油酸、总碳水化合物和果糖饮食摄入量相关的dTGA风险增加，而与较低的总蛋白和蛋氨酸摄入量相关的TOF风险降低。即使同时调整了其他研究的营养素，膳食中几种微量营养素的摄入量较低，即叶酸、烟酸、核黄素和维生素B12、A和E，也与dTGA的风险增加有关，但与TOF无关。这些协会中观察到的妇女谁不使用维生素补充剂periconceptionally。对几个潜在混杂因素的分析考虑并未揭示结果的其他解释。我们的人群为基础的病例对照研究试图扩大营养和心脏缺陷的风险和预防的知识基础。
Evidence exists for an association between maternal use of a vitamin supplement with folic acid in early pregnancy and a reduced risk for offspring with conotruncal heart defects. Few inquiries about periconceptional nutrition, other than folate, and risk of heart defects have been made. Data derived from a population-based case-control study of fetuses and liveborn infants among a cohort of California births between July 1999 and June 2004. In total, 76% of eligible case mothers and 77% of eligible control mothers were interviewed. Cases included 140 with d-transposition of great arteries (dTGA), and 163 with tetralogy of Fallot (TOF). Total number of controls was 698. Self-reported use of vitamins was elicited by questionnaire for the periconceptional period, Dietary nutrient intake was elicited by a well-known food frequency questionnaire. The odds ratio for dTGA associated with supplemental vitamin use was 1.0 (95% confidence interval, 0.7-1.5) and for TOF was 0.9 (0.6-1.3). We observed increased risks associated with lower dietary intakes of linoleic acid, total carbohydrate, and fructose for dTGA, whereas decreased risks were observed for lower intakes of total protein and methionine for TOF. Lower dietary intake of several micronutrients, namely folate, niacin, riboflavin, and vitamins B12, A, and E, even after simultaneous adjustment for other studied nutrients, were associated with increased risks of dTGA, but not for TOF. These associations were observed among women who did not use vitamin supplements periconceptionally. Analytic consideration of several potential confounders did not reveal alternative interpretations of the results. Our population-based case-control study attempted to extend the knowledge base on nutrition and heart defect risk and prevention.
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影响因子：
0.7
作者：
Lammer, EJ;Scholes, T;Abrams, L
通讯作者：
Abrams, L
DOI：
10.1002/bdra.20541
发表时间：
2009-01-01
影响因子：
--
作者：
Lammer, Edward J.;Chak, Jacqueline S.;Shaw, Gary M.
通讯作者：
Shaw, Gary M.
影响因子：
5
作者：
FERENCZ, C;RUBIN, JD;DOWNING, JW
通讯作者：
DOWNING, JW
DOI：
10.1111/j.1467-842x.2006.tb00867.x
发表时间：
2006-06-01
影响因子：
3.5
作者：
Bower, Carol;Miller, Margaret;Serna, Peta
通讯作者：
Serna, Peta
影响因子：
5
作者：
BLOCK, G;HARTMAN, AM;GARDNER, L
通讯作者：
GARDNER, L