Impact of depression on mental fatigue and attention in patients with multiple sclerosis
Impact of depression on mental fatigue and attention in patients with multiple sclerosis
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抑郁症对多发性硬化症患者精神疲劳和注意力的影响
DOI：
10.1016/j.jadr.2021.100143
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发表时间：
2021
影响因子：
--
通讯作者：
Itoh Yoshiaki
中科院分区：
文献类型：
--
作者：
Takeda Akitoshi;Minatani Shinobu;Ishii Akira;Matsuo Takashi;Tanaka Masaaki;Yoshikawa Takahiro;Itoh Yoshiaki
背景：抑郁和疲劳是多发性硬化症（MS）的衰弱症状，影响认知功能。本研究旨在探讨抑郁与疲劳之间的关系，以及抑郁或疲劳是否会影响MS患者的认知。方法选取20例多发性硬化症患者。使用Chalder疲劳量表（CFS）评估疲劳的严重程度，该量表对CFS_Physical和CFS_Mental疲劳和MMSE进行分类。采用贝克抑郁量表（BDI）评估抑郁程度。通过几个任务来评估注意力缺陷。比较MS患者与健康对照组（hc）的CFS评分、BDI评分及注意任务中的表现。研究了CFS分值、BDI值与参与者注意力表现之间的相关性。结果MS患者的总CFS、BDI和MMSE评分明显低于hc患者（p< 0.05）。CFS_Mental分值与注意任务表现显著相关（p <0.05）。重度抑郁的MS患者的注意力测试得分最差，CFS_Mental亚分显著高于其他MS患者和hc。重度抑郁症患者BDI评分与病程相关。在其余MS患者中，注意测试和BDI评分与hc患者没有显著差异。本研究样本量小，限制了推广。运动前认知功能不匹配。结论精神疲劳与注意缺陷密切相关。抑郁症影响多发性硬化症患者的精神疲劳和注意力。
1BackgroundDepression and fatigue are debilitating symptoms in multiple sclerosis (MS), which affect cognitive function. This study investigated the association between depression and fatigue, and whether depression or fatigue influences cognition in MS patients.MethodsTwenty MS patients were included. The severity of fatigue was assessed using the Chalder Fatigue Scale (CFS), which classified CFS_Physical and CFS_Mental fatigue and MMSE. Depression was assessed using the Beck Depression Inventory (BDI). Attention deficit was evaluated using several tasks. The CFS scores, the BDI scores and performance during the attention tasks were compared between MS patients and healthy control subjects (HCs). Correlations between CFS sub-scores, BDI values, and participants’ attention performance were also investigated.ResultsThe total CFS, BDI, and MMSE scores were significantly worse in MS patients compared to HCs (p< 0.05). The CFS_Mental sub-score was significantly correlated with performance on attention tasks (p <0.05). MS patients with severe depression exhibited the worst scores on attention tests and significantly higher CFS_Mental sub-scores than the remaining MS patients and HCs. The BDI scores of MS patients with severe depression correlated with disease duration. In the remaining MS patients, attention tests and BDI scores did not differ significantly from those in HCs.LimitationsThis study had a small sample size, which limits generalization. Premobid cognitive functions were not matched.ConclusionMental fatigue is closely associated with attention deficit. Depression affects mental fatigue and attention in MS patients.
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DOI：
10.1093/arclin/acs113
发表时间：
2013
期刊：
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists
影响因子：
--
作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
2003
期刊：
Multiple Sclerosis
影响因子：
--
作者：
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影响因子：
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DOI：
10.1016/j.apmr.2018.11.005
发表时间：
2019-05-01
影响因子：
4.3
作者：
Krause, James S.;Dismuke-Greer, Clara E.;Rumrill, Phillip
通讯作者：
Rumrill, Phillip