The sequence of structural, functional and cognitive changes in multiple sclerosis.
The sequence of structural, functional and cognitive changes in multiple sclerosis.
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DOI：
10.1016/j.nicl.2020.102550
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Wottschel V
中科院分区：
文献类型：
--
作者：
Dekker I;Schoonheim MM;Venkatraghavan V;Eijlers AJC;Brouwer I;Bron EE;Klein S;Wattjes MP;Wink AM;Geurts JJG;Uitdehaag BMJ;Oxtoby NP;Alexander DC;Vrenken H;Killestein J;Barkhof F;Wottschel V
由于对多发性硬化症 (MS) 的疾病进展仍知之甚少，我们的目标是使用一种新颖的数据驱动方法来研究不同疾病里程碑发生的顺序。我们分析了 295 名复发性多发性硬化症患者和 96 名健康对照者的队列，并考虑了 28 个特征，捕获了有关 T2 病变负荷、区域大脑和脊髓体积、静息态功能中心性（“hubness”）、主要白质 (WM) 束的微结构组织完整性以及多项认知测试表现的信息。我们使用基于事件的判别模型来估计多发性硬化症进展中生物标志物异常的序列，以及针对身体残疾和认知障碍恶化的特定模型。我们证明，小脑、丘脑的灰质 (GM) 萎缩和皮质脊髓束的变化是 MS 病理学的早期事件，而其他 WM 束以及工作记忆、注意力和执行功能的认知领域始终是晚期事件。与一般多发性硬化症人群相比，残疾和认知模型显示默认模式网络的早期功能变化和脊髓体积的早期变化。总体而言，GM 萎缩似乎至关重要，因为它早期参与病程，而 WM 束完整性似乎相对较晚受到影响，尽管 WM 病变较早发生。数据驱动的建模揭示了随着多发性硬化症进展，成像和非成像事件的相对发生率，提供了对疾病传播机制的见解，并允许对患者进行细粒度分期以进行监测
As disease progression remains poorly understood in multiple sclerosis (MS), we aim to investigate the sequence in which different disease milestones occur using a novel data-driven approach. We analysed a cohort of 295 relapse-onset MS patients and 96 healthy controls, and considered 28 features, capturing information on T2-lesion load, regional brain and spinal cord volumes, resting-state functional centrality (“hubness”), microstructural tissue integrity of major white matter (WM) tracts and performance on multiple cognitive tests. We used a discriminative event-based model to estimate the sequence of biomarker abnormality in MS progression in general, as well as specific models for worsening physical disability and cognitive impairment. We demonstrated that grey matter (GM) atrophy of the cerebellum, thalamus, and changes in corticospinal tracts are early events in MS pathology, whereas other WM tracts as well as the cognitive domains of working memory, attention, and executive function are consistently late events. The models for disability and cognition show early functional changes of the default-mode network and earlier changes in spinal cord volume compared to the general MS population. Overall, GM atrophy seems crucial due to its early involvement in the disease course, whereas WM tract integrity appears to be affected relatively late despite the early onset of WM lesions. Data-driven modelling revealed the relative occurrence of both imaging and non-imaging events as MS progresses, providing insights into disease propagation mechanisms, and allowing fine-grained staging of patients for monitoring purposes
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影响因子：
4.3
作者：
Klein A;Tourville J
通讯作者：
Tourville J
多发性硬化症患者认知功能与蝶鞍束高分辨率弥散张量核磁共振成像之间的关系。
DOI：
10.1177/1352458515576983
发表时间：
2015-12
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Koenig KA;Sakaie KE;Lowe MJ;Lin J;Stone L;Bermel RA;Beall EB;Rao SM;Trapp BD;Phillips MD
通讯作者：
Phillips MD
影响因子：
19.7
作者：
Eijlers, Anand J. C.;Meijer, Kim A.;Schoonheim, Menno M.
通讯作者：
Schoonheim, Menno M.
影响因子：
4.2
作者：
Ingala, Silvia;Mazzai, Linda;Barkhof, Frederik
通讯作者：
Barkhof, Frederik
影响因子：
2.3
作者：
Dekker, Iris;Wattjes, Mike P.
通讯作者：
Wattjes, Mike P.