Social reward processing: A biomarker for predicting psychosis risk?
Social reward processing: A biomarker for predicting psychosis risk?
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DOI：
10.1016/j.schres.2018.07.042
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发表时间：
2020-12
影响因子：
4.5
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Pelletier-Baldelli A;Orr JM;Bernard JA;Mittal VA
获得社会奖励（例如积极反馈）的愿望在我们的生活和关系中非常突出，并且与理解精神病理学有关-行为经常受损。鉴于社会功能受损和社会孤立的比例很高，调查精神病谱系内的社会奖励提供了一个特别有用的机会。本研究的目的是调查与社会奖励处理相关的享乐体验作为精神病风险的潜在生物标志物。本研究采用基于任务的功能性磁共振成像（fMRI）范式，在青少年在临床上高风险的精神病（NMD，n = 19）和健康的未受影响的同龄人（健康对照- HC，n = 20）的发展。腹内侧前额叶皮层和腹侧纹状体的区域激活和连接进行了检查，以响应接收积极的社会反馈相对于一个模糊的反馈条件。预期受损的享乐过程中，一般不支持，因为有神经反应或任务为基础的连接没有组间差异。虽然有趣的关系被发现连接神经奖励反应和连接与社会，预期，和消费性快感缺失的研究小组，结果是很难解释的任务限制。我们讨论了未来的研究设计，寻求调查社会奖励处理作为精神病风险的生物标志物的潜在影响。
The desire to obtain social rewards (e.g. positive feedback) features prominently in our lives and relationships, and is relevant to understanding psychopathology – where behavior is often impaired. Investigating social rewards within the psychosis-spectrum offers an especially useful opportunity, given the high rates of impaired social functioning and social isolation. The goal of this study was to investigate hedonic experience associated with social reward processing as a potential biomarker for psychosis risk. This study used a task-based functional magnetic resonance imaging (fMRI) paradigm in adolescents at clinical high-risk for the development of psychosis (CHR, n = 19) and healthy unaffected peers (healthy controls – HC, n = 20). Regional activation and connectivity of the ventromedial prefrontal cortex and ventral striatum were examined in response to receiving positive social feedback relative to an ambiguous feedback condition. Expectations of impaired hedonic processes in CHR youth were generally not supported, as there were no group differences in neural response or task-based connectivity. Although interesting relationships were found linking neural reward response and connectivity with social, anticipatory, and consummatory anhedonia in the CHR group, results are difficult to interpret in light of task limitations. We discuss potential implications for future study designs that seek to investigate social reward processing as a biomarker for psychosis risk.
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影响因子：
2
作者：
Strobl EV;Eack SM;Swaminathan V;Visweswaran S
通讯作者：
Visweswaran S
影响因子：
4.2
作者：
Davis, F. Caroline;Neta, Maital;Whalen, Paul J.
通讯作者：
Whalen, Paul J.
影响因子：
2.6
作者：
Diekhof, Esther Kristina;Kaps, Lisa;Gruber, Oliver
通讯作者：
Gruber, Oliver
DOI：
10.1126/science.aac9698
发表时间：
2016-01-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ferenczi EA;Zalocusky KA;Liston C;Grosenick L;Warden MR;Amatya D;Katovich K;Mehta H;Patenaude B;Ramakrishnan C;Kalanithi P;Etkin A;Knutson B;Glover GH;Deisseroth K
通讯作者：
Deisseroth K
影响因子：
6.7
作者：
Collip, D.;Wigman, J. T. W.;Myin-Germeys, I.
通讯作者：
Myin-Germeys, I.