Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus.
Homeostatic properties and phenotypic maturation of murine CD4+ pre-thymic emigrants in the thymus.
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DOI：
10.1371/journal.pone.0056378
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ge Q
中科院分区：
文献类型：
--
作者：
Dong J;Chen Y;Xu X;Jin R;Teng F;Yan F;Tang H;Li P;Sun X;Li Y;Wu H;Zhang Y;Ge Q
在胸腺经过严格调控的发育程序后，“成熟”的单阳性(SP)胸腺细胞离开胸腺进入外周。这些新近到达的胸腺移民者(RTE)在表型和功能上都不成熟，在被许可为常驻幼稚T细胞之前，将在外周淋巴器官完成动态成熟。为了研究RTE成熟过程中发生的早期事件，我们确定了CD4+前rte的表型，这是一组获得了胸腺出口能力的CD4+SP胸腺细胞。与外周幼稚T细胞相比，CD4+前体细胞在淋巴缺乏的小鼠中表现出更好的生存能力，并且在淋巴细胞减少的条件下增殖更快。Bcl2/Bim表达的差异和/或IL-7信号通路的增强可能是Pre-rte对动态平衡信号有较好反应的原因。表明SPS和RTES表型成熟的QA2在胸腺血管周围间隙的CD4+前体细胞中表达上调。环绕该区域的迁移性树突状细胞有助于在Pre-rte中表达QA2。树突状细胞驱动的QA2对CD4+前体细胞的诱导不依赖于MHC II类和Aire分子。
After a tightly regulated developmental program in the thymus, “mature” single positive (SP) thymocytes leave the thymus and enter the periphery. These newly arrived recent thymic emigrants (RTEs) are phenotypically and functionally immature, and will complete a dynamic maturation in the peripheral lymphoid organs before being licensed to be resident naïve T cells. To study the early events occurring in the RTE maturation process, we identified the phenotype of CD4+ pre-RTEs, a population of CD4+ SP thymocytes that have acquired the thymus egress capability. Compared to peripheral naïve T cells, CD4+ pre-RTEs displayed superior survival capability in lymphoreplete mice and faster proliferation under lymphopenic condition. The differences in Bcl2/Bim expression and/or heightened IL-7 signaling pathway may account for the pre-RTEs’ better responsiveness to homeostatic signals. Qa2, the expression of which indicates the phenotypic maturation of SPs and RTEs, was found to be upregulated in CD4+ pre-RTEs in thymic perivascular space. Migratory dendritic cells that surround this region contribute to Qa2 expression in pre-RTEs. The dendritic cell-driven Qa2 induction of CD4+ pre-RTEs is independent of MHC class II and Aire molecules.
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DOI：
10.1084/jem.185.2.263
发表时间：
1997-01-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Kishimoto H;Sprent J
通讯作者：
Sprent J
胸腺归巢外周树突状细胞构成稳态胸腺中树突状细胞的三个主要亚群中的两个。
影响因子：
15.3
作者：
Li, JiChu;Park, JooHung;Foss, Deborah;Goldschneider, Irving
通讯作者：
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DOI：
10.1084/jem.20080996
发表时间：
2009-02-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
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通讯作者：
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DOI：
10.4049/jimmunol.181.8.5213
发表时间：
2008-10-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Houston EG Jr;Nechanitzky R;Fink PJ
通讯作者：
Fink PJ
DOI：
10.1073/pnas.96.17.9787
发表时间：
1999-08-17
影响因子：
11.1
作者：
Berzins, SP;Godfrey, DI;Boyd, RL
通讯作者：
Boyd, RL