Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012.
Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012.
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DOI：
10.1038/jid.2013.274
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发表时间：
2014-01
影响因子：
6.5
通讯作者：
Margolis, David J.
中科院分区：
文献类型：
--
作者：
Sargen, Michael R.;Hoffstad, Ole;Margolis, David J.
关于儿童在冬季和夏季沿着湿疹流行的全球变化而发生湿疹发作的轶事报道引发了气候可能调节疾病活动的猜测。本研究的目的是确定长期天气模式是否影响儿童湿疹症状的严重程度和持续时间。我们对2004年至2012年参加PEER（儿科湿疹选择性登记）的美国儿童（N= 5，595）进行了一项前瞻性队列研究，以评估气候（每日温度，每日阳光照射，每日湿度）对湿疹症状严重程度的影响。计算患者评估疾病控制结果的比值比。调整性别、种族、收入和外用药物使用的多变量logistic回归模型显示，较高的温度（OR= 0.90，95% CI：0.87 - 0.93，p<0.001）和增加的阳光照射（OR= 0.93，95% CI：0.89 - 0.98，p= 0.009）与湿疹控制不良相关。较高的湿度（OR= 0.90，95%CI：0.812 -0.997，p= 0.04）也与疾病控制不佳相关，但在我们的多变量分析中，这种相关性的统计学显著性丢失（p=0.44）。
Anecdotal reports of children experiencing eczema flares during winter and summer months along with global variation in eczema prevalence has fueled speculation that climate may modulate disease activity. The aim of this study was to determine if long-term weather patterns affect the severity and persistence of eczema symptoms in children. We performed a prospective cohort study of U.S. children (N=5,595) enrolled in PEER (Pediatric Eczema Elective Registry) between 2004 and 2012 to evaluate the effect of climate (daily temperature, daily sun exposure, daily humidity) on the severity of eczema symptoms. Odds ratios were calculated for the patient evaluated outcome of disease control. Multivariate logistic regression modeling adjusting for gender, race, income, and topical medication use demonstrated that higher temperature (OR=0·90, 95% CI: 0·87–0·93, p<0·001) and increased sun exposure (OR=0·93, 95% CI: 0·89–0·98, p=0·009) were associated with poorly controlled eczema. Higher humidity (OR=0·90, 95% CI: 0·812–0.997, p=0·04) was also associated with poorly controlled disease, but the statistical significance of this association was lost in our multivariate analysis (p=0.44).
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