Advancing the science on cannabis concentrates and behavioural health.
Advancing the science on cannabis concentrates and behavioural health.
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DOI：
10.1111/dar.13281
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发表时间：
2021-09
影响因子：
3.8
通讯作者：
Karoly, Hollis C.
中科院分区：
文献类型：
--
作者：
Bidwell, L. Cinnamon;Martin-Willett, Renee;Karoly, Hollis C.
大麻植物含有数百种植物大麻素，但公认对公共健康风险最重要的是具有精神活性的大麻素-9-四氢大麻酚(THC)，它与大麻使用障碍、情感障碍、认知损害和精神运动障碍的风险有关。最近，通过从植物中提取大麻类物质以形成THC浓度高达90-95%的产品而制成的浓缩大麻产品(或“浓缩物”)的使用和可获得性有所增加。这些产品在全国范围内越来越受欢迎。关于这些广泛可用的高效力浓缩物的文献有限，关于它们的潜在危害还有许多未知之处。这项审查涵盖了关于大麻浓缩物和与行为健康有关的结果的研究现状，并提出了促进科学发展的建议，研究的重点是准确测试与关键的公共和行为健康问题有关的风险。数据表明，浓缩液的使用对行为健康有独特的影响。然而，关于大麻浓缩物影响的因果、受控和代表性研究目前有限。未来的研究需要探索浓缩物的慢性、急性和发育影响，以及对肺功能的影响。我们还强调了在不同人群中探索这些关系的必要性。虽然文献暗示这些高度有效的产品有可能增加与大麻有关的行为健康危害，但重要的是仔细设计研究，更全面地评估浓缩物对THC暴露的影响以及对使用者群体的短期和长期影响。
The Cannabis sativa L. plant contains hundreds of phytocannabinoids, but putatively of highest importance to public health risk is the psychoactive cannabinoid delta-9-tetrahydrocannabinol (THC), which is associated with risk for cannabis use disorder, affective disturbance, cognitive harm and psychomotor impairment. Recently, there has been an increase in the use and availability of concentrated cannabis products (or ‘concentrates’) that are made by extracting cannabinoids from the plant to form a product with THC concentrations as high as 90–95%. These products are increasingly popular nationwide. The literature on these widely available high potency concentrates is limited and there are many unknowns about their potential harms. This review covers the state of the research on cannabis concentrates and behavioural health-related outcomes and makes recommendations for advancing the science with studies focused on accurately testing the risks in relation to critical public and behavioural health questions. Data point to unique behavioural health implications of concentrate use. However, causal, controlled and representative research on the effects of cannabis concentrates is currently limited. Future research is needed to explore chronic, acute and developmental effects of concentrates, as well as effects on pulmonary function. We also highlight the need to explore these relationships in diverse populations. While the literature hints at the potential for these highly potent products to increase cannabis-related behavioural health harms, it is important to carefully design studies that more comprehensively evaluate the impact of concentrates on THC exposure and short- and long-term effects across user groups.
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