Incident Impaired Cognitive Function in Sarcopenic Obesity: Data From the National Health and Aging Trends Survey.
Incident Impaired Cognitive Function in Sarcopenic Obesity: Data From the National Health and Aging Trends Survey.
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DOI：
10.1016/j.jamda.2020.09.008
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发表时间：
2021-04
影响因子：
7.6
通讯作者：
Mackenzie TA
中科院分区：
文献类型：
--
作者：
Batsis JA;Haudenschild C;Roth RM;Gooding TL;Roderka MN;Masterson T;Brand J;Lohman MC;Mackenzie TA
在≥65岁的成年人中，肥胖伴石棺减少的患病率正在增加。这种老年综合征将个体置于导致长期功能衰退的协同并发症的风险中。在一个具有代表性的美国人群中，我们确定了骨源性肥胖与长期全球认知功能受损事件之间的关系。使用全国健康和老龄化趋势调查进行的纵向二级数据集分析。美国以社区为基础的老年人。没有基线损害的认知功能受试者年龄65岁，采用握力和身体质量指数测量≥。骨质疏松症的定义是使用美国国立卫生研究院萨科普尼亚项目基金会的握力切割点(男性35.5公斤；女性20公斤)，肥胖是使用标准身体质量指数(BMI)类别定义的。整体认知受损被确定为阿尔茨海默病-8分或立即/延迟回忆、定向、抽钟测试、日期/人回忆的损害。比例风险模型确定了8年内认知功能受损的风险(参照物=既非肥胖也非骨质疏松症)。在5822名参与者(55.7%的女性)中，年龄中位数为75岁至80岁，平均握力和BMI分别为26.4公斤和27.5公斤/平方米。骨性肥胖症的基线患病率为12.9%，在随访时观察到21.2%的参与者认知功能受损。与无骨质疏松症或肥胖者相比，单纯肥胖者认知功能受损的风险无差异[危险比(HR)0.98；95%可信区间(CI)0.82~1.16]，但骨质疏松症(HR 1.60；95%CI 1.42~1.80)和骨质疏松症(HR 1.20；95%CI 1.03~1.40)显著高于肥胖组(HR 1.20；95%CI 1.03~1.40)。骨质疏松症和肥胖症之间没有显著的交互作用。骨质疏松症和骨质疏松性肥胖都与老年人认知功能受损的长期风险增加有关。
The prevalence of obesity with sarcopenia is increasing in adults aged ≥65 years. This geriatric syndrome places individuals at risk for synergistic complications that leads to long-term functional decline. We ascertained the relationship between sarcopenic obesity and incident long-term impaired global cognitive function in a representative US population. A longitudinal, secondary data set analysis using the National Health and Aging Trends Survey. Community-based older adults in the United States. Participants without baseline impaired cognitive function aged ≥65 years with grip strength and body mass index measures. Sarcopenia was defined using the Foundation for the National Institutes of Health Sarcopenia Project grip strength cut points (men <35.5 kg; women <20 kg), and obesity was defined using standard body mass index (BMI) categories. Impaired global cognition was identified as impairment in the Alzheimer’s Disease-8 score or immediate/delayed recall, orientation, clock-draw test, date/person recall. Proportional hazard models ascertained the risk of impaired cognitive function over 8 years (referent = neither obesity or sarcopenia). Of the 5822 participants (55.7% women), median age category was 75 to 80, and mean grip strength and BMI were 26.4 kg and 27.5 kg/m2, respectively. Baseline prevalence of sarcopenic obesity was 12.9%, with an observed subset of 21.2% participants having impaired cognitive function at follow-up. Compared with those without sarcopenia or obesity, the risk of impaired cognitive function was no different in obesity alone [hazard ratio (HR) 0.98; 95% confidence interval (CI) 0.82–1.16]), but was significantly higher in sarcopenia (HR 1.60; 95% CI 1.42–1.80) and sarcopenic obesity (HR 1.20; 95% CI 1.03–1.40). There was no significant interaction term between sarcopenia and obesity. Both sarcopenia and sarcopenic obesity are associated with an increased long-term risk of impaired cognitive function in older adults.
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影响因子：
37.8
作者：
Jensen MD;Ryan DH;Apovian CM;Ard JD;Comuzzie AG;Donato KA;Hu FB;Hubbard VS;Jakicic JM;Kushner RF;Loria CM;Millen BE;Nonas CA;Pi-Sunyer FX;Stevens J;Stevens VJ;Wadden TA;Wolfe BM;Yanovski SZ;Jordan HS;Kendall KA;Lux LJ;Mentor-Marcel R;Morgan LC;Trisolini MG;Wnek J;Anderson JL;Halperin JL;Albert NM;Bozkurt B;Brindis RG;Curtis LH;DeMets D;Hochman JS;Kovacs RJ;Ohman EM;Pressler SJ;Sellke FW;Shen WK;Smith SC Jr;Tomaselli GF;American College of Cardiology/American Heart Association Task Force on Practice Guidelines;Obesity Society
通讯作者：
Obesity Society
影响因子：
3.3
作者：
Kera, Takeshi;Kawai, Hisashi;Obuchi, Shuichi
通讯作者：
Obuchi, Shuichi
影响因子：
5.8
作者：
Deckers, Kay;van Boxtel, M. P. J.;Kohler, S.
通讯作者：
Kohler, S.
影响因子：
5
作者：
Haapanen, N;Miilunpalo, S;Vuori, I
通讯作者：
Vuori, I
影响因子：
9.9
作者：
Galvin, James E.;Roe, Catherine M.;Morris, John C.
通讯作者：
Morris, John C.