Integrin-dependence of lymphocyte entry into the splenic white pulp.
Integrin-dependence of lymphocyte entry into the splenic white pulp.
复制标题
淋巴细胞进入脾白髓的整合素依赖性。
DOI：
10.1084/jem.20021569
复制
发表时间：
2003-02-03
期刊：
影响因子：
--
通讯作者：
Cyster JG
中科院分区：
文献类型：
--
作者：
Lo CG;Lu TT;Cyster JG
淋巴细胞归巢到脾的白色髓索的步骤还不清楚。我们在此证明，淋巴细胞功能相关的整合素（LFA）-1和α4β1对B细胞迁移到白色髓索中起到了重要的作用，而且大部分是重叠的。T细胞进入白色牙髓也通过LFA-1和α4β1的阻断而减少。LFA-1配体，细胞间粘附分子1是淋巴细胞进入的关键，造血细胞和抗辐射细胞都有助于这一要求。血管细胞粘附分子1有助于α4β1配体的需求，第二种配体，可能是纤连蛋白，也起作用。与进入要求相反，抗原诱导的B细胞从卵泡到外T区的运动不被整合素阻断抗体阻止。整合素阻断的B细胞和Gαi抑制剂百日咳毒素处理的B细胞在转移后早期的分布比较显示，在两种情况下，内边缘区的蓄积减少。这些观察结果表明，趋化因子受体信号传导和整合素LFA-1和α4β1共同起作用，以促进淋巴细胞从边缘区转运到白色髓索中。
The steps involved in lymphocyte homing to the white pulp cords of the spleen are poorly understood. We demonstrate here that the integrins lymphocyte function associated (LFA)-1 and α4β1 make essential and mostly overlapping contributions necessary for B cell migration into white pulp cords. T cell entry to the white pulp is also reduced by blockade of LFA-1 and α4β1. The LFA-1 ligand, intercellular adhesion molecule 1 is critical for lymphocyte entry and both hematopoietic cells and radiation-resistant cells contribute to this requirement. Vascular cell adhesion molecule 1 contributes to the α4β1 ligand requirement and a second ligand, possibly fibronectin, also plays a role. By contrast with the entry requirements, antigen-induced movement of B cells from follicles to the outer T zone is not prevented by integrin blocking antibodies. Comparison of the distribution of integrin-blocked B cells and B cells treated with the Gαi inhibitor, pertussis toxin, early after transfer reveals in both cases reduced accumulation in the inner marginal zone. These observations suggest that chemokine receptor signaling and the integrins LFA-1 and α4β1 function together to promote lymphocyte transit from the marginal zone into white pulp cords.
登录
查看更多内容
影响因子：
3.6
作者：
BRELINSKA, R;PILGRIM, C;REISERT, I
通讯作者：
REISERT, I
影响因子：
5.4
作者：
LYONS, AB;PARISH, CR
通讯作者：
PARISH, CR
DOI：
10.1084/jem.194.2.219
发表时间：
2001-07-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Henderson RB;Lim LH;Tessier PA;Gavins FN;Mathies M;Perretti M;Hogg N
通讯作者：
Hogg N
CD18无效小鼠的自发皮肤溃疡和T细胞功能缺陷。
DOI：
10.1084/jem.188.1.119
发表时间：
1998-07-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Scharffetter-Kochanek K;Lu H;Norman K;van Nood N;Munoz F;Grabbe S;McArthur M;Lorenzo I;Kaplan S;Ley K;Smith CW;Montgomery CA;Rich S;Beaudet AL
通讯作者：
Beaudet AL
影响因子：
5.4
作者：
BRENAN, M;PARISH, CR
通讯作者：
PARISH, CR