Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
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来自1,098个表型较深的个体的微生物组与宿主代谢和习惯性饮食的关系。
DOI：
10.1038/s41591-020-01183-8
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发表时间：
2021-03
期刊：
影响因子：
82.9
通讯作者：
Segata N
中科院分区：
文献类型：
--
作者：
Asnicar F;Berry SE;Valdes AM;Nguyen LH;Piccinno G;Drew DA;Leeming E;Gibson R;Le Roy C;Khatib HA;Francis L;Mazidi M;Mompeo O;Valles-Colomer M;Tett A;Beghini F;Dubois L;Bazzani D;Thomas AM;Mirzayi C;Khleborodova A;Oh S;Hine R;Bonnett C;Capdevila J;Danzanvilliers S;Giordano F;Geistlinger L;Waldron L;Davies R;Hadjigeorgiou G;Wolf J;Ordovás JM;Gardner C;Franks PW;Chan AT;Huttenhower C;Spector TD;Segata N
肠道微生物群由饮食塑造，并影响宿主的代谢，但这些联系是复杂的，对每个人来说都是独一无二的。我们对来自具有详细长期饮食信息的个体的bb101100个肠道微生物组进行了深度宏基因组测序，并对数百个禁食和同餐后心脏代谢血液标志物进行了测量。我们发现微生物与特定营养素、食物、食物组和一般饮食指标之间存在很强的关联，特别是受到健康和植物性食物的存在和多样性的推动。肥胖的微生物生物标志物在整个队列中是可重复的，心血管疾病和糖耐量受损的血液标志物与微生物组结构的相关性更强。一些微生物如copri Prevotella和Blastocystis spp是有利的餐后葡萄糖代谢的指标，一些物种更直接地预测餐后甘油三酯和c肽。与健康饮食习惯相关的肠道菌群与与有利的心脏代谢和餐后标志物相关的菌群重叠，表明我们的大规模资源有可能在没有临床表现疾病的个体中将肠道菌群分层为可推广的健康水平。
The gut microbiome is shaped by diet and influences host metabolism, but these links are complex and can be unique to each individual. We performed deep metagenomic sequencing of >1,100 gut microbiomes from individuals with detailed long-term diet information, as well as hundreds of fasting and same-meal postprandial cardiometabolic blood marker measurements. We found strong associations between microbes and specific nutrients, foods, food groups, and general dietary indices, driven especially by the presence and diversity of healthy and plant-based foods. Microbial biomarkers of obesity were reproducible across cohorts, and blood markers of cardiovascular disease and impaired glucose tolerance were more strongly associated with microbiome structure. While some microbes such as Prevotella copri and Blastocystis spp., were indicators of favorable postprandial glucose metabolism, several species were more directly predictive of postprandial triglycerides and C-peptide. The panel of intestinal species associated with healthy dietary habits overlapped with those associated with favourable cardiometabolic and postprandial markers, indicating our large-scale resource can potentially stratify the gut microbiome into generalizable health levels among individuals without clinically manifest disease.
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影响因子：
82.9
作者：
Berry SE;Valdes AM;Drew DA;Asnicar F;Mazidi M;Wolf J;Capdevila J;Hadjigeorgiou G;Davies R;Al Khatib H;Bonnett C;Ganesh S;Bakker E;Hart D;Mangino M;Merino J;Linenberg I;Wyatt P;Ordovas JM;Gardner CD;Delahanty LM;Chan AT;Segata N;Franks PW;Spector TD
通讯作者：
Spector TD
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
9.2
作者：
Dhakan, D. B.;Maji, A.;Sharma, V. K.
通讯作者：
Sharma, V. K.
影响因子：
56.9
作者：
Falony, Gwen;Joossens, Marie;Raes, Jeroen
通讯作者：
Raes, Jeroen
影响因子：
4.8
作者：
Guenther, Patricia M.;Casavale, Kellie O.;Reedy, Jill;Kirkpatrick, Sharon I.;Hiza, Hazel A. B.;Kuczynski, Kevin J.;Kahle, Lisa L.;Krebs-Smith, Susan M.
通讯作者：
Krebs-Smith, Susan M.