Marine sponge lectins: actual status on properties and biological activities.

Marine sponge lectins: actual status on properties and biological activities.
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DOI:
10.3390/molecules20010348
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发表时间:
2014-12-26
期刊:
Molecules (Basel, Switzerland)
影响因子:
--
通讯作者:
de Almeida Gadelha CA
de Almeida Gadelha CA
中科院分区:
其他
文献类型:
--
作者:
Gomes Filho SM;Cardoso JD;Anaya K;Silva do Nascimento E;de Lacerda JT;Mioso R;Santi Gadelha T;de Almeida Gadelha CA

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海洋海绵是原始的后生动物,它们产生各种各样的分子来保护自己免受捕食者的侵害。在寻找生物活性分子的研究中,这些海洋无脊椎动物作为新的生物活性分子的有希望的来源脱颖而出,其中许多仍然未知或研究很少;是一种未开发的高附加值生物技术资源。在这些分子中,凝集素是一种与碳水化合物可逆结合而不改变它们的蛋白质。本文综述了迄今为止科学文献中从海绵中提取的凝集素的各种结构特征和生物活性。从文献结果可以看出,从海绵中提取的凝集素是一种结构多样的蛋白质,在生物制药生产中具有很大的应用潜力,特别是在抗菌和抗肿瘤方面。
Marine sponges are primitive metazoans that produce a wide variety of molecules that protect them against predators. In studies that search for bioactive molecules, these marine invertebrates stand out as promising sources of new biologically-active molecules, many of which are still unknown or little studied; thus being an unexplored biotechnological resource of high added value. Among these molecules, lectins are proteins that reversibly bind to carbohydrates without modifying them. In this review, various structural features and biological activities of lectins derived from marine sponges so far described in the scientific literature are discussed. From the results found in the literature, it could be concluded that lectins derived from marine sponges are structurally diverse proteins with great potential for application in the production of biopharmaceuticals, especially as antibacterial and antitumor agents.
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