Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis.
Asymmetric loading and bone mineral density at the asymptomatic knees of patients with unilateral hip osteoarthritis.
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DOI：
10.1002/art.30626
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发表时间：
2011-12
影响因子：
--
通讯作者：
Block, Joel A.
中科院分区：
文献类型：
--
作者：
Shakoor, Najia;Dua, Anisha;Thorp, Laura E.;Mikolaitis, Rachel A.;Wimmer, Markus A.;Foucher, Kharma C.;Fogg, Louis F.;Block, Joel A.
已知单侧终末期髋关节 OA 患者的对侧膝关节发生终末期膝关节 OA 的风险高于同侧同侧膝关节。同样，在终末期髋关节 OA 中，与同侧膝关节相比，对侧膝关节的动态关节负荷增加。在这里，我们研究了患有单侧髋关节 OA 的人群，他们的膝盖没有症状，早期膝盖负荷不对称。对 62 名单侧髋关节 OA 受试者的数据进行了评估。受试者接受步态分析以评估动态膝关节负荷，并接受双能 X 射线吸收测定法以评估双膝骨矿物质密度 (BMD)。比较膝盖之间的差异。与同侧膝关节相比，对侧膝关节的峰值动态膝关节负荷显着更高（2.46±0.71 vs 2.23±0.81%BW*ht，p=0.029）。同样，对侧膝关节的胫骨内侧间室 BMD 显着高于同侧膝关节（0.897±0.208 vs 0.854±0.206 gm/c2，p=0.033）。有趣的是，对侧：同侧动态膝关节负荷与对侧：同侧胫骨内侧间室 BMD 之间存在直接相关性（Spearman’s rho = 0.287，p = 0.036）。这项研究表明，单侧髋关节 OA 患者的对侧膝关节比同侧膝关节发展为进行性症状性 OA 的风险更高，在病程早期就出现负荷和结构不对称，而膝关节仍无症状。这些早期生物力学不对称可能会产生相应的长期后果，为负荷在 OA 发病和进展中的潜在作用提供了进一步的支持。
The contralateral knee of those with unilateral endstage hip OA is known to be at greater risk for endstage knee OA compared to the ipsilateral, same side knee. Likewise, in endstage hip OA, this contralateral knee is known to have increased dynamic joint loads compared to the ipsilateral knee. Here, we study a population with unilateral hip OA, who are asymptomatic at the knees, for early asymmetries in knee loading. Data from 62 subjects with unilateral hip OA were evaluated. Subjects underwent gait analyses for evaluation of dynamic knee loads as well as dual energy X-ray absorptiometry for evaluation of bone mineral density (BMD) at both knees. Differences between knees were compared. Peak dynamic knee loads were significantly higher at the contralateral knee compared to the ipsilateral knee (2.46±0.71 vs 2.23±0.81 %BW*ht, p=0.029). Similarly, medial compartment tibial BMD was significantly higher at the contralateral knee compared to the ipsilateral knee (0.897±0.208 vs 0.854±0.206 gm/c2, p=0.033). Interestingly, there was a direct correlation between contralteral:ipsilateral dynamic knee load and contralateral:ipsilateral medial compartment tibial BMD (Spearman’s rho= 0.287, p=0.036). This study demonstrates that at the contralateral knees of patients with unilateral hip OA, which are at higher risk of developing progressive symptomatic OA compared to the ipsilateral knees, loading and structural asymmetries appear early in the disease course, while the knees are still asymptomatic. These early biomechanical asymmetries may have corresponding long term consequences, providing further support for the potential role of loading in OA onset and progression.
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影响因子：
3.5
作者：
McGrory, BJ;Harris, WH
通讯作者：
Harris, WH
影响因子：
5.5
作者：
Wada, M;Maezawa, Y;Nose, Y
通讯作者：
Nose, Y
DOI：
10.2106/00004623-198264090-00008
发表时间：
1982-01-01
影响因子：
5.3
作者：
ANDRIACCHI, TP;GALANTE, JO;FERMIER, RW
通讯作者：
FERMIER, RW
影响因子：
--
作者：
FELSON, DT;ZHANG, YQ;LEVY, D
通讯作者：
LEVY, D
影响因子：
--
作者：
SCHNITZER, TJ;POPOVICH, JM;ANDRIACCHI, TP
通讯作者：
ANDRIACCHI, TP