Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration.
Longitudinal Analysis of Adiponectin through 20-Year Type 1 Diabetes Duration.
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DOI：
10.1155/2015/730407
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发表时间：
2015
影响因子：
4.3
通讯作者：
Palta M
中科院分区：
文献类型：
--
作者：
LeCaire TJ;Palta M
脂联素是一种可能的胰岛素增敏剂，也是炎症和内皮功能的标志物，在1型糖尿病的病程中，脂联素的变化轨迹和决定因素的信息很少。威斯康星州糖尿病登记研究随访了1987-1992年期间诊断为1型糖尿病的≤30岁的事件队列长达20年。在2007年至2011年期间，对参与20年检查的患者（n = 304）进行了同时和回顾性测量（来自冷冻在-80 °C下的样本）。女性的脂联素水平较高，在青春期下降，此后随着年龄的增长而增加。较低的水平与较大的体重和腰围以及较高的胰岛素剂量相关，特别是在较长的糖尿病病程中。更高的水平与更高的HbA 1c相关，并且在更长的持续时间内，与更高的白蛋白-肌酐比值相关。脂联素水平在个体内表现出一致性，这不能用这些因素来解释。我们的结论是胰岛素抵抗的标志物与较低的脂联素相关，而潜在的微血管并发症的标志物与较高的脂联素相关。先前报告的与HbA 1c的关系在很大程度上仍然无法解释。其他个体特异性因素也可能影响脂联素水平。脂联素和尿蛋白排泄之间的关系可能有助于识别1型糖尿病早期肾脏疾病的易感性。
Little information exists on the trajectory and determinants of adiponectin, a possible insulin sensitizer and marker for inflammation and endothelial function, across the duration of type 1 diabetes. The Wisconsin Diabetes Registry Study followed an incident cohort ≤30 years of age when diagnosed with type 1 diabetes during 1987–1992 up to 20-year duration. Adiponectin was concurrently and retrospectively (from samples frozen at −80°C) measured for those participating in a 20-year exam (n = 304), during 2007–2011. Adiponectin levels were higher in females, declined through adolescence, and increased with age thereafter. Lower levels were associated with greater body weight and waist circumference and with higher insulin dose, especially at longer diabetes durations. Higher levels were associated with higher HbA1c and, at longer durations, with higher albumin-creatinine ratio. Adiponectin levels showed consistency within individuals that was not explained by these factors. We conclude that markers for insulin resistance are associated with lower adiponectin, and markers for potential microvascular complications are associated with higher adiponectin. The previously reported relationship with HbA1c remains largely unexplained. Additional individual specific factors likely also influence adiponectin level. The relationship between adiponectin and urinary protein excretion may enable identification of those predisposed to kidney disease earlier in type 1 diabetes.
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