Maternal and offspring pools of osteocalcin influence brain development and functions.
Maternal and offspring pools of osteocalcin influence brain development and functions.
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DOI：
10.1016/j.cell.2013.08.042
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发表时间：
2013-09-26
期刊：
影响因子：
64.5
通讯作者：
Karsenty G
中科院分区：
文献类型：
--
作者：
Oury F;Khrimian L;Denny CA;Gardin A;Chamouni A;Goeden N;Huang YY;Lee H;Srinivas P;Gao XB;Suyama S;Langer T;Mann JJ;Horvath TL;Bonnin A;Karsenty G
大脑对骨量的强大调节表明存在骨源性信号调节这种调节或大脑的其他功能。我们在这里表明，成骨细胞衍生的激素骨钙素穿过血脑屏障，与脑干，中脑和海马的神经元结合，增强单胺神经递质的合成，抑制GABA的合成，防止焦虑和抑郁，并有利于学习和记忆，独立于其代谢功能。除了这些产后功能，母体骨钙素在怀孕期间穿过胎盘，并在胚胎合成这种激素之前防止神经元凋亡。因此，骨钙素−/−小鼠的神经解剖缺陷和学习记忆缺陷的严重程度取决于母体基因型，将骨钙素输送给怀孕的骨钙素−/−小鼠可以挽救其骨钙素−/−后代的这些异常。这项研究表明，骨骼通过骨钙素影响认知，并有助于母亲对胎儿大脑发育的影响。
The powerful regulation of bone mass exerted by the brain suggests the existence of bone-derived signals modulating this regulation or other functions of the brain. We show here that the osteoblast-derived hormone osteocalcin crosses the blood-brain barrier, binds to neurons of the brainstem, midbrain and hippocampus, enhances the synthesis of monoamine neurotransmitters, inhibits GABA synthesis, prevents anxiety and depression and favors learning and memory independently of its metabolic functions. In addition to these post-natal functions, maternal osteocalcin crosses the placenta during pregnancy and prevents neuronal apoptosis before embryos synthesize this hormone. As a result the severity of the neuro-anatomical defects and learning and memory deficits of Osteocalcin−/− mice is determined by the maternal genotype, and delivering osteocalcin to pregnant Osteocalcin−/− mothers rescues these abnormalities in their Osteocalcin−/− progeny. This study reveals that the skeleton via osteocalcin influences cognition and contributes to the maternal influence on fetal brain development.
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影响因子：
64.5
作者：
Ferron M;Wei J;Yoshizawa T;Del Fattore A;DePinho RA;Teti A;Ducy P;Karsenty G
通讯作者：
Karsenty G
影响因子：
2.7
作者：
ENNACEUR, A;DELACOUR, J
通讯作者：
DELACOUR, J
DOI：
10.1073/pnas.0308744101
发表时间：
2004-03-02
影响因子：
11.1
作者：
Elefteriou, F;Takeda, S;Karsenty, G
通讯作者：
Karsenty, G
影响因子：
64.5
作者：
Lee, Na Kyung;Sowa, Hideaki;Karsenty, Gerard
通讯作者：
Karsenty, Gerard
影响因子：
14.8
作者：
Goeden N;Bonnin A
通讯作者：
Bonnin A