International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I).
International Chronic Ocular Graft-vs-Host-Disease (GVHD) Consensus Group: proposed diagnostic criteria for chronic GVHD (Part I).
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DOI：
10.1038/srep03419
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发表时间：
2013-12-05
影响因子：
4.6
通讯作者：
Tsubota, Kazuo
中科院分区：
文献类型：
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作者：
Ogawa, Yoko;Kim, Stella K.;Dana, Reza;Clayton, Janine;Jain, Sandeep;Rosenblatt, Mark I.;Perez, Victor L.;Shikari, Hasanain;Riemens, Anjo;Tsubota, Kazuo
国际慢性眼部移植物抗宿主病共识小组举行了4次工作会议，以确定慢性眼部移植物抗宿主病(GVHD)的新诊断指标。在考虑了目前用于诊断慢性眼部GVHD的因素后，Consensus Group确定了异基因造血干细胞移植(HSCT)后患者需要测量的4个主客观变量：OSDI、在没有麻醉的情况下Schirmer评分、角膜染色和结膜注射。每个变量的得分为0-2或0-3，最高综合得分为11。还考虑了是否存在全身性移植物抗宿主病。根据他们的综合评分和全身性GVHD的存在或不存在，患者被分为三种诊断类型之一：无、可能或明确的眼部GVHD。共识小组提出了慢性眼部移植物抗宿主病的新诊断标准。需要进行验证研究，以确定建议的指标的最佳组合，以最大限度地提高诊断的灵敏度和特异度。
The International Chronic Ocular GVHD Consensus Group held 4 working meetings to define new diagnostic metrics for chronic ocular graft-versus-host disease (GVHD). After considering the factors currently used to diagnose chronic ocular GVHD, the Consensus Group identified 4 subjective and objective variables to measure in patients following allogeneic hematopoietic stem cell transplantation (HSCT): OSDI, Schirmer's score without anesthesia, corneal staining, and conjunctival injection. Each variable was scored 0–2 or 0–3, with a maximum composite score of 11. Consideration was also given to the presence or the absence of systemic GVHD. On the basis of their composite score and the presence or absence of systemic GVHD, patients were assigned to one of three diagnostic categories: NO, PROBABLE, or DEFINITE ocular GVHD. New diagnostic criteria for chronic ocular GVHD are presented by the Consensus Group. Validation studies are needed to identify the best combination of the proposed metrics to maximize diagnostic sensitivity and specificity.
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影响因子：
2
作者：
Kamoi, Mizuka;Ogawa, Yoko;Tsubota, Kazuo
通讯作者：
Tsubota, Kazuo
影响因子：
--
作者：
JABS, DA;WINGARD, J;SARAL, R
通讯作者：
SARAL, R
影响因子：
13.7
作者：
Balaram, M;Dana, MR
通讯作者：
Dana, MR
影响因子：
13.7
作者：
Inamoto Y;Chai X;Kurland BF;Cutler C;Flowers ME;Palmer JM;Carpenter PA;Heffernan MJ;Jacobsohn D;Jagasia MH;Pidala J;Khera N;Vogelsang GB;Weisdorf D;Martin PJ;Pavletic SZ;Lee SJ;Chronic GVHD Consortium
通讯作者：
Chronic GVHD Consortium
影响因子：
--
作者：
HIRST, LW;JABS, DA;TUTSCHKA, PJ
通讯作者：
TUTSCHKA, PJ