Missing and delayed auditory responses in young and older children with autism spectrum disorders.
Missing and delayed auditory responses in young and older children with autism spectrum disorders.
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DOI：
10.3389/fnhum.2014.00417
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发表时间：
2014
影响因子：
2.9
通讯作者：
Roberts TP
中科院分区：
文献类型：
--
作者：
Edgar JC;Lanza MR;Daina AB;Monroe JF;Khan SY;Blaskey L;Cannon KM;Jenkins J 3rd;Qasmieh S;Levy SE;Roberts TP
背景：研究典型发育期(TD)儿童和自闭症谱系障碍(ASD)儿童左右侧颞上回(STG)50 ms(M50)和100 ms(M100)听觉反应的发育情况。这反映了初级/次级听觉区域的不同发育，并支持了先前的研究，假设尽管左右M50 STG反应在年龄较小和年龄较大的儿童中同样常见，但左右M100 STG反应在年龄较小的儿童中更常缺失。在ASD患者中，观察到ASD患者在两个年龄组中都有更大比例的ASD患者表现出缺失的M100而不是M50反应，这表明神经发育迟缓。缺失的M100反应主要发生在有语言障碍(ASD + Li)的自闭症儿童(可能伴随着一般认知能力低下)。方法：3 5例TD对照组、6 3例无语言障碍的房间隔缺陷症(ASD − LI)和38例ASD + LI。呈现了双耳音调。对有无STG M50和M100进行评分。受试者被分为年轻组(6-10 岁)和老年组(11-15 岁)。结果：尽管M50反应在老年人和年轻人以及TD和ASD中同样常见，但ASD − LI和ASD + LI的左右M50反应延迟。两组比较显示，在年轻受试者中，TD组M100反应率高于ASD + LI组(90%vs66%，p = 0.0 4)，TD组与ASD − LI组间差异无统计学意义(90%vs76%，p = 0.14)，ASD − LI组与ASD + LI组间无差异(76%vs66%，p = 0.53)。在老年人中，TD和ASD + LI之间没有差异，ASD − LI的反应比ASD + LI更常见。将ASD组分为认知功能较低和认知功能较高的两组时，研究结果类似。结论：虽然在所有组中都存在M50反应，但ASD患者的M50反应延迟。检查TD数据的结果表明，到11 年时，100%的受试者应该观察到右侧M100，80%的受试者观察到左侧M100。因此，到了11个 年龄段，缺少左M100，尤其是右M100，提供了对可能导致语言或认知障碍的感觉处理的神经生物学洞察。
Background: The development of left and right superior temporal gyrus (STG) 50 ms (M50) and 100 ms (M100) auditory responses in typically developing (TD) children and in children with autism spectrum disorder (ASD) was examined. Reflecting differential development of primary/secondary auditory areas and supporting previous studies, it was hypothesized that whereas left and right M50 STG responses would be observed equally often in younger and older children, left and right M100 STG responses would more often be absent in younger than older children. In ASD, delayed neurodevelopment would be indicated via the observation of a greater proportion of ASD than TD subjects showing missing M100 but not M50 responses in both age groups. Missing M100 responses would be observed primarily in children with ASD with language impairment (ASD + LI) (and perhaps concomitantly lower general cognitive abilities). Methods: Thirty-five TD controls, 63 ASD without language impairment (ASD − LI), and 38 ASD + LI were recruited. Binaural tones were presented. The presence or absence of a STG M50 and M100 was scored. Subjects were grouped into younger (6–10 years old) and older groups (11–15 years old). Results: Although M50 responses were observed equally often in older and younger subjects and equally often in TD and ASD, left and right M50 responses were delayed in ASD − LI and ASD + LI. Group comparisons showed that in younger subjects M100 responses were observed more often in TD than ASD + LI (90 versus 66%, p = 0.04), with no differences between TD and ASD − LI (90 versus 76%, p = 0.14) or between ASD − LI and ASD + LI (76 versus 66%, p = 0.53). In older subjects, whereas no differences were observed between TD and ASD + LI, responses were observed more often in ASD − LI than ASD + LI. Findings were similar when splitting the ASD group into lower- and higher-cognitive functioning groups. Conclusion: Although present in all groups, M50 responses were delayed in ASD. Examining the TD data, findings indicated that by 11 years, a right M100 should be observed in 100% of subjects and a left M100 in 80% of subjects. Thus, by 11 years, lack of a left and especially right M100 offers neurobiological insight into sensory processing that may underlie language or cognitive impairment.
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影响因子：
3.9
作者：
Cornew, Lauren;Roberts, Timothy P. L.;Blaskey, Lisa;Edgar, J. Christopher
通讯作者：
Edgar, J. Christopher
影响因子：
4.7
作者：
Ceponiene, R;Rinne, T;Näätänen, R
通讯作者：
Näätänen, R
DOI：
10.1016/0168-5597(94)90018-3
发表时间：
1994-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
MAKELA, JP;HAMALAINEN, M;MCEVOY, L
通讯作者：
MCEVOY, L
影响因子：
3
作者：
Marshall, PJ;Bar-Haim, Y;Fox, NA
通讯作者：
Fox, NA
DOI：
10.1016/0168-5597(86)90017-1
发表时间：
1986-09-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
ERWIN, R;BUCHWALD, JS
通讯作者：
BUCHWALD, JS