Resting-state oscillatory activity in autism spectrum disorders.
Resting-state oscillatory activity in autism spectrum disorders.
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DOI：
10.1007/s10803-011-1431-6
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发表时间：
2012-09
影响因子：
3.9
通讯作者：
Edgar, J. Christopher
中科院分区：
文献类型：
--
作者：
Cornew, Lauren;Roberts, Timothy P. L.;Blaskey, Lisa;Edgar, J. Christopher
自闭症谱系障碍 (ASD) 中的神经振荡异常表明存在兴奋/抑制失衡；然而，这些异常的性质和临床相关性尚不清楚。收集了 50 名儿童（27 名自闭症谱系障碍儿童，23 名对照儿童）接受闭眼静息状态检查时的全皮质脑磁图数据。应用快速傅立叶变换并检查 15 个区域源的 1 至 120 Hz 振荡活动。探讨了振荡异常与症状严重程度之间的关联。患有自闭症谱系障碍 (ASD) 的儿童表现出 δ (1-4 Hz)、θ (4-8 Hz)、α (8-12 Hz) 和高频 (20-120 Hz) 功率的区域特定升高，支持神经兴奋/抑制失衡作为自闭症谱系障碍的神经生物学特征。颞叶和顶叶 α 功率的增加与症状严重程度增加相关，因此特别令人感兴趣。
Neural oscillatory anomalies in autism spectrum disorders (ASD) suggest an excitatory/inhibitory imbalance; however, the nature and clinical relevance of these anomalies are unclear. Whole-cortex magnetoencephalography data were collected while 50 children (27 with ASD, 23 controls) underwent an eyes-closed resting-state exam. A Fast Fourier Transform was applied and oscillatory activity examined from 1 to 120 Hz at 15 regional sources. Associations between oscillatory anomalies and symptom severity were probed. Children with ASD exhibited regionally specific elevations in delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), and high frequency (20–120 Hz) power, supporting an imbalance of neural excitation/inhibition as a neurobiological feature of ASD. Increased temporal and parietal alpha power was associated with greater symptom severity and thus is of particular interest.
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