Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.
Characterization of neutralizing versus binding antibodies and memory B cells in COVID-19 recovered individuals from India.
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DOI：
10.1016/j.virol.2021.02.002
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发表时间：
2021-06
期刊：
影响因子：
3.7
通讯作者：
Chandele A
中科院分区：
文献类型：
--
作者：
Nayak K;Gottimukkala K;Kumar S;Reddy ES;Edara VV;Kauffman R;Floyd K;Mantus G;Savargaonkar D;Goel PK;Arora S;Rahi M;Davis CW;Linderman S;Wrammert J;Suthar MS;Ahmed R;Sharma A;Murali-Krishna K;Chandele A
印度是受COVID-19大流行影响最严重的国家之一;但对该地区对SARS-CoV-2的免疫反应知之甚少。在此，我们检测了来自印度的COVID-19康复者的SARS-CoV-2中和抗体、IgG、IgM、伊加和记忆B细胞。虽然绝大多数COVID-19康复者显示SARS-CoV-2 RBD特异性IgG、伊加和IgM抗体（分别为38/42，90.47%; 21/42，50%; 33/42，78.57%），但只有一半人具有明显的中和抗体滴度。RBD特异性IgG，而不是伊加或IgM滴度，与中和抗体滴度和RBD特异性记忆B细胞频率相关。这些发现对于在印度使用RBD特异性IgG测定作为中和抗体的替代测量来确定血浆治疗的潜在供体具有及时的意义。此外，这项研究还为设计大规模研究提供了有用的信息，以了解SARS CoV-2自然感染免疫记忆的个体间差异，以便未来的疫苗评估和实施工作。
India is one of the most affected countries by COVID-19 pandemic; but little is understood regarding immune responses to SARS-CoV-2 in this region. Herein we examined SARS-CoV-2 neutralizing antibodies, IgG, IgM, IgA and memory B cells in COVID-19 recovered individual from India. While a vast majority of COVID-19 recovered individuals showed SARS-CoV-2 RBD-specific IgG, IgA and IgM antibodies (38/42, 90.47%; 21/42, 50%; 33/42, 78.57% respectively), only half of them had appreciable neutralizing antibody titers. RBD-specific IgG, but not IgA or IgM titers, correlated with neutralizing antibody titers and RBD-specific memory B cell frequencies. These findings have timely significance for identifying potential donors for plasma therapy using RBD-specific IgG assays as surrogate measurement for neutralizing antibodies in India. Further, this study provides useful information needed for designing large-scale studies towards understanding of inter-individual variation in immune memory to SARS CoV-2 natural infection for future vaccine evaluation and implementation efforts.
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