Regulation of Inhibin and Activin Genes in the Rat Ovary

Regulation of Inhibin and Activin Genes in the Rat Ovary
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大鼠卵巢中抑制素和激活素基因的调控

DOI:
10.1007/978-1-4612-3200-1_8
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发表时间:
1991
影响因子:
2.7
通讯作者:
K. Mayo
K. Mayo
中科院分区:
医学3区
文献类型:
--
作者:
J. C. Dykema;J. O. Rahal;K. Mayo

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促性腺激素、促黄体生成激素(LH)和促卵泡激素(FSH)通过影响性腺的配子生成和类固醇生成功能,在调节哺乳动物生殖周期中发挥重要作用(1,2)。已知垂体前叶促性腺激素细胞同时释放LH和FSH受到下丘脑十肽GnRH的正调控(3,4)。最近,已经分离和鉴定了几种特异性调节FSH合成和分泌的性腺肽。这些包括促卵泡素、激活素和卵泡抑素(5-12)。
The gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), play major roles in regulating the mammalian reproductive cycle by influencing the gametogenic and steroidogenic functions of the gonads (1, 2). The simultaneous release of LH and FSH from anterior pituitary gonadotrophs is known to be positively regulated by the hypothalamic decapeptide GnRH (3,4). More recently, several gonadal peptides that specifically modulate FSH synthesis and secretion have been isolated and characterized. These include the inhibins, activins, and follistatin (5-12).
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