Evidence for avian H9N2 influenza virus infections among rural villagers in Cambodia.
Evidence for avian H9N2 influenza virus infections among rural villagers in Cambodia.
复制标题
DOI：
10.1016/j.jiph.2012.11.005
复制
发表时间：
2013-04
影响因子：
6.7
通讯作者：
Gray, Gregory C.
中科院分区：
文献类型：
--
作者：
Blair, Patrick J.;Putnam, Shannon D.;Krueger, Whitney S.;Chum, Channimol;Wierzba, Thomas F.;Heil, Gary L.;Yasuda, Chadwick Y.;Williams, Maya;Kasper, Matthew R.;Friary, John A.;Capuano, Ana W.;Saphonn, Vonthanak;Peiris, Malik;Shao, Hongxia;Perez, Daniel R.;Gray, Gregory C.
东南亚仍然是出现新型和/或人畜共患流感的关键地区，这突出表明在最有可能发生早期传播的农村地区进行广泛采样的重要性。2008年，来自8个地点的800名成年参与者参加了一项基于人群的禽流感（AI）病毒传播前瞻性研究，其中2006年至2008年报告了人类和家禽中的高致病性禽流感（HPAI）H5 N1病毒。从他们的登记血清和问卷调查，我们报告的危险因素的血清学证据以前感染18禽流感病毒株的结果。血清学检测显示，没有证据表明以前感染过13种不同的低致病性禽流感病毒或高致病性禽流感病毒样A/柬埔寨/R 0404050/2007（H5 N1）。然而，21名参与者对禽流感样A/Hong Kong/1073/1999（H9 N2）的抗体升高，经禽流感H9特异性单克隆抗体阻断ELISA检测验证。虽然不能完全排除抗人类流感病毒抗体的交叉反应，但研究数据表明，一些参与者先前感染了禽流感样A/Hong Kong/1073/1999（H9 N2）病毒，可能是由于尚未确定的环境暴露。来自该队列的前瞻性数据将帮助我们更好地了解东南亚农村队列中人畜共患流感感染的血清学。
Southeast Asia remains a critical region for the emergence of novel and/or zoonotic influenza, underscoring the importance of extensive sampling in rural areas where early transmission is most likely to occur. In 2008, 800 adult participants from eight sites were enrolled in a prospective population-based study of avian influenza (AI) virus transmission where highly pathogenic avian influenza (HPAI) H5N1 virus had been reported in humans and poultry from 2006 to 2008. From their enrollment sera and questionnaires, we report risk factor findings for serologic evidence of previous infection with 18 AI virus strains. Serologic assays revealed no evidence of previous infection with 13 different low-pathogenic AI viruses or with HPAI avian-like A/Cambodia/R0404050/2007(H5N1). However, 21 participants had elevated antibodies against avian-like A/Hong Kong/1073/1999(H9N2), validated with a monoclonal antibody blocking ELISA assay specific for avian H9. Although cross-reaction from antibodies against human influenza viruses cannot be completely excluded, the study data suggest that a number of participants were previously infected with the avian-like A/Hong Kong/1073/1999(H9N2) virus, likely due to as yet unidentified environmental exposures. Prospective data from this cohort will help us better understand the serology of zoonotic influenza infection in a rural cohort in SE Asia.
登录
查看更多内容
影响因子：
8.8
作者：
Cavailler, Philippe;Chu, Simon;Buchy, Philippe
通讯作者：
Buchy, Philippe
影响因子：
11.8
作者：
Vong S;Ly S;Mardy S;Holl D;Buchy P
通讯作者：
Buchy P
影响因子：
6.4
作者：
Vong, Sirenda;Ly, Sowath;Katz, Jacqueline M.
通讯作者：
Katz, Jacqueline M.
影响因子：
168.9
作者：
Peiris, M;Yuen, KY;Shortridge, KF
通讯作者：
Shortridge, KF
影响因子：
4.4
作者：
Capuano, Ana W.;Dawson, Jeffrey D.;Gray, Gregory C.
通讯作者：
Gray, Gregory C.