Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group
Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group
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松果体实质肿瘤中间分化的临床病理学分析：九州神经肿瘤学研究组的多机构队列研究
DOI：
10.1007/s11060-023-04310-w
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发表时间：
2023
影响因子：
3.9
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Yamashita Shinji;Takeshima Hideo;Ujifuku Kenta;et al.
目的中分化松果体肿瘤(PPTIDs)是一种少见的肿瘤，在所有中枢神经系统肿瘤中所占比例不到1%，2007年世界卫生组织(WHO)对其进行了分类。这种罕见性和新颖性使PPTID的诊断和治疗变得复杂。因此，我们的目的是评估该肿瘤的临床病理意义。方法在参加九州神经肿瘤研究组的11个机构中，收集了诊断为PPTID的患者的数据。结果28例PPTID患者中11例(39%)为WHO 2级肿瘤，17例(61%)为WHO 3级肿瘤。年龄中位数为49岁，男女比例为1：2.1。所有28例患者均接受了手术治疗，其中46%(13/28)的患者获得了大体全切除。辅助放疗和化疗分别为82%(23/28)和46%(13/28)。5年无进展生存率和总生存率分别为64.9%和70.4%。女性(p = 0.018)和Gtr(p <； 0.01)是PFS的独立预后因素，女性(p = 0.019)是OS的独立预后因素。首次和第二次复发最常见的是软脑膜(分别为67%和100%)。80%(20/25)的患者存在KBTBD4突变。结论女性性别和GTR是影响PPTID患者预后的独立因素。软脑膜复发是该肿瘤的特殊特征。在我们的队列中观察到的KBTBD4突变率是可以接受的，这可以证明我们的PPTID队列的准确性。
PurposePineal parenchymal tumors of intermediate differentiation (PPTIDs), which were recognized in the 2007 World Health Organization (WHO) classification, are rare, accounting for less than 1% of all central nervous system tumors. This rarity and novelty complicate the diagnosis and treatments of PPTID. We therefore aimed to evaluate the clinicopathological significance of this tumor.MethodsAt 11 institutions participating in the Kyushu Neuro-Oncology Study Group, data for patients diagnosed with PPTID were collected. Central pathology review andKBTBD4mutation analysis were applied to attain the diagnostically accurate cohort.ResultsPPTID was officially diagnosed in 28 patients: 11 (39%) with WHO grade 2 and 17 (61%) with WHO grade 3 tumors. Median age was 49 years, and the male:female ratio was 1:2.1. Surgery was attempted in all 28 patients, and gross total resection (GTR) was achieved in 46% (13/28). Adjuvant radiotherapy and chemotherapy were administered to, respectively, 82% (23/28) and 46% (13/28). The 5-year progression-free survival (PFS) and overall survival rates were 64.9% and 70.4% respectively. Female sex (p = 0.018) and GTR (p < 0.01) were found to be independent prognostic factors for PFS and female sex (p = 0.019) was that for OS. Initial and second recurrences were most often leptomeningeal (67% and 100% respectively). 80% (20/25) of patients harbored aKBTBD4mutation.ConclusionsFemale sex and GTR were independent prognostic factors in our patients with PPTID. Leptomeningeal recurrence was observed to be particularly characteristic of this tumor. The rate ofKBTBD4mutation observed in our cohort was acceptable and this could prove the accuracy of our PPTID cohort.
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松果体实质肿瘤中分化的临床病理学研究。
影响因子：
2
作者：
Tamio Ito;Hiromi Kanno;Kenichi Sato;Mitsuteru Oikawa;Y. Ozaki;Hirohiko Nakamura;S. Terasaka;Hiroyuki Kobayashi;K. Houkin;K. Hatanaka;Jyun;S. Tanaka
通讯作者：
S. Tanaka
影响因子：
3.3
作者：
MENA, H;RUSHING, EJ;MCCARTHY, WF
通讯作者：
MCCARTHY, WF
成人松果体母细胞瘤治疗和预后的性别差异。
DOI：
10.1016/j.ijrobp.2021.07.1004
发表时间：
2021
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
K. Nam;S. Madishetty;Ş. Kılıç;M. Dinh;J. Scott;S. Chao;E. Murphy;K. Yang;J. Suh
通讯作者：
J. Suh
影响因子：
3.9
作者：
Lu, Victor M.;Luther, Evan M.;Ivan, Michael E.
通讯作者：
Ivan, Michael E.
松果体细胞瘤和中间分化的松果体实质肿瘤呈现细胞学多形性：一项多中心研究
影响因子：
6.4
作者：
M. Fèvre;A. Szathmari;J. Champier;K. Mokhtari;F. Chrétien;A. Coulon;D. Figarella;M. Polivka;P. Varlet;E. Uro;F. Fauchon;A. Jouvet
通讯作者：
A. Jouvet