Intergenerational epigenetic inheritance in models of developmental programming of adult disease.
Intergenerational epigenetic inheritance in models of developmental programming of adult disease.
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DOI：
10.1016/j.semcdb.2015.06.006
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发表时间：
2015-07
影响因子：
7.3
通讯作者：
Ozanne SE
中科院分区：
文献类型：
--
作者：
Fernandez-Twinn DS;Constância M;Ozanne SE
现在已经确定，我们在胎儿和新生儿生命期间所暴露的环境可能对我们的健康产生长期影响。这被称为健康和疾病的发展起源。已知具有这种编程效应的因素包括宫内营养素的可用性（由母体营养和胎盘功能决定）、内分泌干扰物、毒素和传染性病原体。表观遗传过程已经成为一种关键机制，通过这种机制，早期环境可以在多轮细胞分裂后永久影响细胞功能和代谢。最近有人提出，程序性效应可以在第一代之后观察到，因此表观遗传机制可能构成表型从父母到孩子到孙辈及以后传播的基础。在这里，我们审查这些过程的证据。
It is now well established that the environment to which we are exposed during fetal and neonatal life can have a long-term impact on our health. This has been termed the developmental origins of health and disease. Factors known to have such programming effects include intrauterine nutrient availability, (determined by maternal nutrition and placental function), endocrine disruptors, toxins and infectious agents. Epigenetic processes have emerged as a key mechanism by which the early environment can permanently influence cell function and metabolism after multiple rounds of cell division. More recently it has been suggested that programmed effects can be observed beyond the first generation and that therefore epigenetic mechanisms could form the basis of transmission of phenotype from parent to child to grandchild and beyond. Here we review the evidence for such processes.
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DOI：
10.1126/science.1229277
发表时间：
2013-01-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hackett JA;Sengupta R;Zylicz JJ;Murakami K;Lee C;Down TA;Surani MA
通讯作者：
Surani MA
影响因子：
64.5
作者：
Carone BR;Fauquier L;Habib N;Shea JM;Hart CE;Li R;Bock C;Li C;Gu H;Zamore PD;Meissner A;Weng Z;Hofmann HA;Friedman N;Rando OJ
通讯作者：
Rando OJ
影响因子：
8.1
作者：
Fernandez-Twinn DS;Alfaradhi MZ;Martin-Gronert MS;Duque-Guimaraes DE;Piekarz A;Ferland-McCollough D;Bushell M;Ozanne SE
通讯作者：
Ozanne SE
影响因子：
25
作者：
Gapp, Katharina;Jawaid, Ali;Sarkies, Peter;Bohacek, Johannes;Pelczar, Pawel;Prados, Julien;Farinelli, Laurent;Miska, Eric;Mansuy, Isabelle M.
通讯作者：
Mansuy, Isabelle M.
影响因子：
64.5
作者：
Huang H;Sabari BR;Garcia BA;Allis CD;Zhao Y
通讯作者：
Zhao Y