Rejuvenated Stem/Progenitor Cells for Cartilage Repair Using the Pluripotent Stem Cell Technology.
Rejuvenated Stem/Progenitor Cells for Cartilage Repair Using the Pluripotent Stem Cell Technology.
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DOI：
10.3390/bioengineering8040046
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发表时间：
2021-04-10
期刊：
影响因子：
--
通讯作者：
Huard J
中科院分区：
文献类型：
--
作者：
Nakayama N;Ravuri S;Huard J
人们普遍认为，成人关节软骨中的软骨缺损从未自发修复，这被认为是年龄相关性退行性关节疾病（如骨关节炎）的主要原因之一。由于软骨下骨（骨髓）细胞的动员和软骨细胞或间充质基质细胞添加到全层缺损中显示出一定程度的修复，因此成人关节软骨中缺乏自我修复活性可归因于成人关节中缺乏修复细胞。相反，在胎儿或胚胎阶段，关节软骨具有无瘢痕修复活性，表明胚胎关节可能含有负责这种活性的细胞，其可以是软骨细胞、软骨祖细胞或其他细胞类型，如骨骼干细胞。在这方面，多能干细胞（PSC）产生胚胎特征细胞的趋势将提供机会，特别是对人类来说，获得携带类似软骨自我修复活性的细胞。利用PSC衍生的细胞进行软骨修复仍处于基础或临床前研究阶段。这篇综述将简要概述人类PSC如何用于软骨修复研究。
It is widely accepted that chondral defects in articular cartilage of adult joints are never repaired spontaneously, which is considered to be one of the major causes of age-related degenerative joint disorders, such as osteoarthritis. Since mobilization of subchondral bone (marrow) cells and addition of chondrocytes or mesenchymal stromal cells into full-thickness defects show some degrees of repair, the lack of self-repair activity in adult articular cartilage can be attributed to lack of reparative cells in adult joints. In contrast, during a fetal or embryonic stage, joint articular cartilage has a scar-less repair activity, suggesting that embryonic joints may contain cells responsible for such activity, which can be chondrocytes, chondroprogenitors, or other cell types such as skeletal stem cells. In this respect, the tendency of pluripotent stem cells (PSCs) to give rise to cells of embryonic characteristics will provide opportunity, especially for humans, to obtain cells carrying similar cartilage self-repair activity. Making use of PSC-derived cells for cartilage repair is still in a basic or preclinical research phase. This review will provide brief overviews on how human PSCs have been used for cartilage repair studies.
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DOI：
10.1073/pnas.1210422109
发表时间：
2012-11-20
影响因子：
11.1
作者：
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