Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling.
Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling.
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DOI：
10.1186/s12987-020-00218-z
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发表时间：
2020-09-22
影响因子：
7.3
通讯作者：
Alsop DC
中科院分区：
文献类型：
--
作者：
Zhao L;Taso M;Dai W;Press DZ;Alsop DC
脉络丛是产生脑脊液（CSF）并维持其电解质和代谢物平衡的主要贡献者。在这里，我们试图使用动脉自旋标记（ASL）MRI来表征脉络丛的血流动力学，以建立ASL作为脉络丛功能和疾病研究的非侵入性工具。7名健康志愿者在3 T MR扫描仪上成像。ASL图像采集有12个标记持续时间和标记后延迟。在高分辨率T1加权图像上手动分割脉络丛区域。采用动态ASL灌注模型表征脉络丛灌注。脑灰质灌注也进行了定量比较。ASL信号的动力学在脉络丛中明显不同于在灰质中。脉络丛的T1明显长于灰质（2.33 ± 0.30 s vs.1.85 ± 0.10 s，p < 0.02）。脉络丛动脉通过时间为1.24 ± 0.20 s。测量到脉络丛的表观血流量为39.5 ± 10.1 ml/100 g/min，在两个半球的后侧脑室上积分为0.80 ± 0.31 ml/min。校正与脉络丛重量产生了80 ml/100 g/min的血流量。我们的研究结果表明，ASL可以提供一个临床可行的选择，以量化脉络丛血流的动态特征。同时也为脉络丛灌注提供了有用的参考值。脉络丛的长T1可能表明水从动脉血运输到CSF，潜在地提供了量化CSF生成的方法。
The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance. Here, we sought to characterize the blood flow dynamics of the choroid plexus using arterial spin labeling (ASL) MRI to establish ASL as a non-invasive tool for choroid plexus function and disease studies. Seven healthy volunteers were imaged on a 3T MR scanner. ASL images were acquired with 12 labeling durations and post labeling delays. Regions of the choroid plexus were manually segmented on high-resolution T1 weighted images. Choroid plexus perfusion was characterized with a dynamic ASL perfusion model. Cerebral gray matter perfusion was also quantified for comparison. Kinetics of the ASL signal were clearly different in the choroid plexus than in gray matter. The choroid plexus has a significantly longer T1 than the gray matter (2.33 ± 0.30 s vs. 1.85 ± 0.10 s, p < 0.02). The arterial transit time was 1.24 ± 0.20 s at the choroid plexus. The apparent blood flow to the choroid plexus was measured to be 39.5 ± 10.1 ml/100 g/min and 0.80 ± 0.31 ml/min integrated over the posterior lateral ventricles in both hemispheres. Correction with the choroid plexus weight yielded a blood flow of 80 ml/100 g/min. Our findings suggest that ASL can provide a clinically feasible option to quantify the dynamic characteristics of choroid plexus blood flow. It also provides useful reference values of the choroid plexus perfusion. The long T1 of the choroid plexus may suggest the transport of water from arterial blood to the CSF, potentially providing a method to quantify CSF generation.
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影响因子：
6.3
作者：
Ennis, Steven R.;Keep, Richard F.
通讯作者：
Keep, Richard F.
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
4.4
作者：
Jessen NA;Munk AS;Lundgaard I;Nedergaard M
通讯作者：
Nedergaard M
DOI：
10.1097/01.wcb.0000046147.31247.e8
发表时间：
2003-02-01
影响因子：
6.3
作者：
Ewing, JR;Wei, L;Fenstermacher, JD
通讯作者：
Fenstermacher, JD
影响因子：
3.3
作者：
Dai, Weiying;Robson, Philip M.;Shankaranarayanan, Ajit;Alsop, David C.
通讯作者：
Alsop, David C.