How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment.
How to entrain a selected neuronal rhythm but not others: open-loop dithered brain stimulation for selective entrainment.
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DOI：
10.1088/1741-2552/acbc4a
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发表时间：
2023-03-07
影响因子：
4
通讯作者：
Bogacz R
中科院分区：
文献类型：
--
作者：
Duchet B;Sermon JJ;Weerasinghe G;Denison T;Bogacz R
虽然脑刺激疗法，如深部脑刺激治疗帕金森病（PD）可能是有效的，但它们尚未充分发挥其在神经系统疾病方面的潜力。在慢性疼痛、抑郁症和阿尔茨海默病等疾病中，使用有节奏的脑刺激来训练神经元节律被认为是一种新的治疗机制，可以恢复神经典型行为。然而，理论和实验证据表明，大脑刺激也可以在远离刺激频率的亚谐波和超谐波处携带神经元节律。至关重要的是，这些违反直觉的影响可能对患者有害，例如，会引发PD患者的不自主运动。因此，我们寻求一种有原则的方法来选择性地促进接近刺激频率的节奏，同时通过防止亚谐波和超谐波的干扰来避免潜在的有害影响。我们的开环方法选择夹带，抖动刺激，包括在刺激期间增加白噪声。我们从理论上建立了抖动刺激选择性地牵引给定脑节律的能力，并在模拟非耦合神经振荡器和耦合神经振荡器网络中验证了其有效性。此外，我们表明，通过在有限的刺激频率范围内切换，可以在功能有限的神经刺激器中实现抖动刺激。可能在各种现有的大脑刺激设备上实现，基于犹豫的选择性带动有可能实现新的大脑刺激疗法，以及利用其调节高阶带动能力的新的神经科学研究。
While brain stimulation therapies such as deep brain stimulation for Parkinson’s disease (PD) can be effective, they have yet to reach their full potential across neurological disorders. Entraining neuronal rhythms using rhythmic brain stimulation has been suggested as a new therapeutic mechanism to restore neurotypical behaviour in conditions such as chronic pain, depression, and Alzheimer’s disease. However, theoretical and experimental evidence indicate that brain stimulation can also entrain neuronal rhythms at sub- and super-harmonics, far from the stimulation frequency. Crucially, these counterintuitive effects could be harmful to patients, for example by triggering debilitating involuntary movements in PD. We therefore seek a principled approach to selectively promote rhythms close to the stimulation frequency, while avoiding potential harmful effects by preventing entrainment at sub- and super-harmonics. Our open-loop approach to selective entrainment, dithered stimulation, consists in adding white noise to the stimulation period. We theoretically establish the ability of dithered stimulation to selectively entrain a given brain rhythm, and verify its efficacy in simulations of uncoupled neural oscillators, and networks of coupled neural oscillators. Furthermore, we show that dithered stimulation can be implemented in neurostimulators with limited capabilities by toggling within a finite set of stimulation frequencies. Likely implementable across a variety of existing brain stimulation devices, dithering-based selective entrainment has potential to enable new brain stimulation therapies, as well as new neuroscientific research exploiting its ability to modulate higher-order entrainment.
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影响因子：
4
作者：
Khaledi-Nasab A;Kromer JA;Tass PA
通讯作者：
Tass PA
影响因子：
5.3
作者：
Brocker DT;Swan BD;Turner DA;Gross RE;Tatter SB;Koop MM;Bronte-Stewart H;Grill WM
通讯作者：
Grill WM
经颅交流电流刺激通过优先刺激皮质神经元的优先相同步来刺激波形，从而吸引了α振荡。
影响因子：
16.6
作者：
Huang WA;Stitt IM;Negahbani E;Passey DJ;Ahn S;Davey M;Dannhauer M;Doan TT;Hoover AC;Peterchev AV;Radtke-Schuller S;Fröhlich F
通讯作者：
Fröhlich F
DOI：
10.1016/j.jpain.2018.09.004
发表时间：
2019-03
期刊：
The journal of pain
影响因子：
--
作者：
Ahn S;Prim JH;Alexander ML;McCulloch KL;Fröhlich F
通讯作者：
Fröhlich F
影响因子：
1.2
作者：
Ermentrout, Bard;Saunders, David
通讯作者：
Saunders, David