Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.
Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform.
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经颅交流电流刺激通过优先刺激皮质神经元的优先相同步来刺激波形，从而吸引了α振荡。
DOI：
10.1038/s41467-021-23021-2
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发表时间：
2021-05-25
影响因子：
16.6
通讯作者：
Fröhlich F
中科院分区：
文献类型：
--
作者：
Huang WA;Stitt IM;Negahbani E;Passey DJ;Ahn S;Davey M;Dannhauer M;Doan TT;Hoover AC;Peterchev AV;Radtke-Schuller S;Fröhlich F
计算建模和人体研究表明，经颅交流电刺激（tACS）通过夹带调节α振荡。然而，一直缺乏对tACS如何与引起丘脑-皮质系统α振荡的神经元尖峰活动相互作用的直接检查。在这里，我们演示了如何tACS夹带内源性α振荡头部固定清醒雪貂。我们首先表明，在后顶叶皮层的内源性α振荡驱动初级视觉皮层和高阶视觉丘脑。尖峰场的相干性是最大的α频带，和假定的快速尖峰抑制性中间神经元表现出最强的耦合到这种振荡。然后，我们应用α-tACS，产生与人类常用的场强相当的场强（<0.5 mV/mm）。在这些雪貂实验和丘脑-皮层系统的计算模型中，tACS通过遵循理论上预测的阿诺德舌头来产生α振荡。有趣的是，在雪貂实验和计算模型中，快速尖峰抑制性中间神经元对tACS表现出更强的夹带反应，这可能是由于它们与α振荡的内源性耦合更强。我们的研究结果证明了tACS调节α振荡的体内作用机制。经颅交流电刺激（tACS）可以调节人类皮层振荡和相关的长期认知和行为功能。在这里，作者提供了在雪貂体内的证据，如何在tACS弱电场可以夹带神经元活动的机制。
Computational modeling and human studies suggest that transcranial alternating current stimulation (tACS) modulates alpha oscillations by entrainment. Yet, a direct examination of how tACS interacts with neuronal spiking activity that gives rise to the alpha oscillation in the thalamo-cortical system has been lacking. Here, we demonstrate how tACS entrains endogenous alpha oscillations in head-fixed awake ferrets. We first show that endogenous alpha oscillations in the posterior parietal cortex drive the primary visual cortex and the higher-order visual thalamus. Spike-field coherence is largest for the alpha frequency band, and presumed fast-spiking inhibitory interneurons exhibit strongest coupling to this oscillation. We then apply alpha-tACS that results in a field strength comparable to what is commonly used in humans (<0.5 mV/mm). Both in these ferret experiments and in a computational model of the thalamo-cortical system, tACS entrains alpha oscillations by following the theoretically predicted Arnold tongue. Intriguingly, the fast-spiking inhibitory interneurons exhibit a stronger entrainment response to tACS in both the ferret experiments and the computational model, likely due to their stronger endogenous coupling to the alpha oscillation. Our findings demonstrate the in vivo mechanism of action for the modulation of the alpha oscillation by tACS. Transcranial alternating current stimulation (tACS) can modulate cortical oscillations and associated long-lasting cognitive and behavioral functions in humans. Here, the authors provide in vivo evidence in ferrets on the mechanism of how weak electric fields in tACS can entrain neuronal activity.
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影响因子：
5.7
作者：
Ahn S;Mellin JM;Alagapan S;Alexander ML;Gilmore JH;Jarskog LF;Fröhlich F
通讯作者：
Fröhlich F
影响因子：
9.8
作者：
Alagapan S;Schmidt SL;Lefebvre J;Hadar E;Shin HW;Frӧhlich F
通讯作者：
Frӧhlich F
影响因子：
3.7
作者：
GEWEKE, JF
通讯作者：
GEWEKE, JF
影响因子：
3.7
作者：
Brignani D;Ruzzoli M;Mauri P;Miniussi C
通讯作者：
Miniussi C
影响因子：
7.7
作者：
Datta, Abhishek;Bansal, Varun;Diaz, Julian;Patel, Jinal;Reato, Davide;Bikson, Marom
通讯作者：
Bikson, Marom