Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study.
Total antioxidant intake in relation to prostate cancer incidence in the Health Professionals Follow-Up Study.
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DOI：
10.1002/ijc.28438
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发表时间：
2014-03-01
影响因子：
6.4
通讯作者：
Mucci, Lorelei A.
中科院分区：
文献类型：
--
作者：
Russnes, Kjell M.;Wilson, Kathryn M.;Epstein, Mara M.;Kasperzyk, Julie L.;Stampfer, Meir J.;Kenfield, Stacey A.;Smeland, Sigbjorn;Blomhoff, Rune;Giovannucci, Edward L.;Willett, Walter C.;Mucci, Lorelei A.
关于抗氧化剂摄入与前列腺癌发病率之间关系的流行病学证据并不一致。总抗氧化剂摄入量与前列腺癌发病率之间的关系此前还没有研究过。采用铁还原抗氧化电位（FRAP）测定法，评估膳食和膳食补充剂中总抗氧化剂含量（TAC）与前列腺癌发病率的关系。从1986年至2008年，47896名年龄在40-75岁之间的男性（N= 5656）参与了前列腺癌发病率的前瞻性队列研究，他们每4年完成一次食物频率问卷（FFQ）。为FFQ中的每个项目分配一个FRAP值，并计算每个个体的饮食，补充剂和两者（总）的TAC分数。基线时TAC摄入量的主要来源是：咖啡（28%）、水果和蔬菜（23%）以及膳食补充剂（23%）。在多变量分析中，饮食TAC呈弱负相关；(最高五分位数vs最低五分位数：总前列腺癌0.91 (0.83-1.00,p-trend=0.03)，晚期前列腺癌0.81 (0.64-1.01,p-trend=0.04)；这种联系主要是由于咖啡。总TAC与前列腺癌发病率无相关性。TAC添加量最高的五分位数分别为1.28 （0.98 ~ 1.65，p趋势<0.01）和1.15 (0.92 ~ 1.43)，p趋势=0.04，与致死性前列腺癌和晚期前列腺癌呈正相关。饮食中抗氧化剂的摄入与前列腺癌发病率降低之间的微弱联系可能与咖啡中特定的抗氧化剂、非抗氧化剂的咖啡化合物或喝咖啡的其他影响有关。从补充剂中摄入高TAC会增加致死性和晚期前列腺癌的风险，这一迹象值得进一步调查。
Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence has not previously been examined. Using the ferric reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and supplements were assessed in relation to prostate cancer incidence. A prospective cohort of 47,896 men aged 40-75 years was followed from 1986 to 2008 for prostate cancer incidence (N=5,656), and they completed food frequency questionnaires (FFQ) every 4 years. A FRAP value was assigned to each item in the FFQ, and for each individual, TAC scores for diet, supplements and both (total) were calculated. Major contributors of TAC intake at baseline were: coffee (28%), fruit and vegetables (23%) and dietary supplements (23%). In multivariate analyses for dietary TAC a weak inverse association was observed; (highest versus lowest quintiles: 0.91 (0.83-1.00, p-trend=0.03) for total prostate cancer, 0.81 (0.64-1.01, p-trend=0.04) for advanced prostate cancer); this association was mainly due to coffee. No association of total TAC on prostate cancer incidence was observed. A positive association with lethal and advanced prostate cancer was observed in the highest quintile of supplemental TAC intake: 1.28 (0.98-1.65, p-trend<0.01) and 1.15 (0.92-1.43), p-trend=0.04). The weak association between dietary antioxidant intake and reduced prostate cancer incidence may be related to specific antioxidants in coffee, to non-antioxidant coffee compounds, or other effects of drinking coffee. The indication of increased risk for lethal and advanced prostate cancer with high TAC intake from supplements warrants further investigation.
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影响因子：
10.3
作者：
Kirsh, VA;Hayes, RB;Peters, U
通讯作者：
Peters, U
影响因子：
10.3
作者：
Wilson, Kathryn M.;Kasperzyk, Julie L.;Mucci, Lorelei A.
通讯作者：
Mucci, Lorelei A.
影响因子：
4.4
作者：
Packer, L;Kraemer, K;Rimbach, G
通讯作者：
Rimbach, G
影响因子：
2.9
作者：
Charlotte, Mari;Myhrstad, Wik;Blomhoff, Rune
通讯作者：
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影响因子：
6.4
作者：
La Vecchia, Carlo;Decarli, Adriano;Rossi, Marta
通讯作者：
Rossi, Marta